中国艾滋病病毒耐药现状

摘要/Abstract

摘要： 艾滋病病毒（HIV）耐药产生和传播将妨碍抗逆转录病毒治疗（ART）防控艾滋病的策略的实施。我国从开展免费抗病毒治疗以来, 逐步推进HIV耐药监测和检测活动, 形成HIV检测监测相结合耐药防控方案。中国目前主要开展传播性耐药监测、治疗前耐药和治疗后耐药评估等。全国多数地区传播性耐药处于低水平, 治疗前非核苷类反转录酶抑制剂（NNRTI）的耐药流行率低于10%。病毒学失败患者约半数以上存在耐药突变。目前我国HIV耐药相对较低, 部分地区耐药增加趋势, 需进一步规范实施耐药监测评估。

关键词: 艾滋病病毒, 耐药, 监测, 抗逆转录病毒治疗

Abstract: The emergence and spread of drug resistant HIV strains can compromise the strategy of using antiretroviral drugs for treating and preventing HIV infection. HIV drug resistance surveillance and monitoring program have been gradually conducted since 2003. The HIV drug resitance operational framework was developed which including HIV drug resistance. Currently, China is mainly engaged in the surveilance of transmitted HIV drug resistance (TDR), pretreatment drug resistance (PDR) in naïve patients and acquired drug resistance (ADR) in individuals on ART. In most areas of China, the prevalence of TDR is relatively low, and the prevalence of non-nucleoside reverse transcriptase inhibitors (NNRTI) PDR is lower than 10%. The prevalence of HIV-1 DR in participants experiencing treatment failure is about 50%.The prevalence of HIV drug resistance is relatively low in China. However, with the increasing number of people receiving antiviral treatment, drug resistance rate increased in some regions. It is important to standardize surveillance and monitoring HIV drug resistance.

Key words: Human immunodeficiency virus (HIV), Drug resistance, Surveillance, Antiretroviral therapy (ART)

吴亚松, 马烨. 中国艾滋病病毒耐药现状[J]. 新发传染病电子杂志, 2019, 4(3): 181-184.

WU Ya-song, MA Ye. CurrentStatus of HIV drug resistance in China[J]. Electronic Journal of Emerging Infectious Diseases, 2019, 4(3): 181-184.

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