南宁市HIV阳性孕产妇接受母婴阻断治疗后18月龄幼儿体格发育不良10年回顾性研究

doi:10.19871/j.cnki.xfcrbzz.2020.04.006

新发传染病电子杂志 ›› 2020, Vol. 5 ›› Issue (4): 243-248.doi: 10.19871/j.cnki.xfcrbzz.2020.04.006

南宁市HIV阳性孕产妇接受母婴阻断治疗后18月龄幼儿体格发育不良10年回顾性研究

葛宪民^1#, 朱金辉^1#, 蒋武², 蓝光华¹, 唐驰³, 李江恒², 林倩³, 陈欢欢¹, 罗柳红¹, 李珊珊¹, 李彬¹, 温平镜¹, 黄玉满¹, 孟琴¹, 刘帅凤¹, 吴秀玲¹, 黄精华¹, 陆华湘¹, 邓月琴¹

1.广西壮族自治区疾病预防控制中心,南宁 530028;
2.南宁市妇幼保健院,南宁 530011;
3.南宁市疾病预防控制中心,南宁 530023

收稿日期:2020-09-26 出版日期:2020-11-30 发布日期:2020-12-31
通讯作者: 葛宪民,Email:gxgexm@sina.com;蒋武,Email:bjbjw@163.com#:并列第一作者
基金资助:
1.国家传染病防治科技重大专项(2018ZX10715008);2.广西壮族自治区科技厅广西重点研发计划项目(桂科AB17195010);3.广西医疗卫生适宜技术开发与推广应用项目(S201685);4.广西八桂学者艾滋病防控关键技术岗位专项(桂办公厅发〔2019〕79号)

A10-year retrospective investigation on the physical development of children aged18months bore by HIV-positive mothers after receiving ART of prevention of mother-to-child transmission of HIV in Nanning

Ge Xianmin¹, Zhu Jinhui¹, Jiang Wu², Lan Guanghua¹, Tang Chi³, Li Jiangheng², Lin Qian³, Chen Huanhuan¹, Luo Liuhong¹, Li Shanshan¹, Li Bin¹, Wen Pingjing¹, Huang Yuman¹, Meng Qin¹, Liu Shuaifeng¹, Wu Xiuling¹, Huang Jinghua¹, Lu Huaxiang¹, Deng Yueqin¹

1. Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning 530028,China;
2. Maternal and child health care of Nanning city,Nanning 530011,China;
3. Center for Disease Control and Prevention of Nanning city,Nanning 530023,China

Received:2020-09-26 Online:2020-11-30 Published:2020-12-31

摘要/Abstract

摘要： 目的分析南宁市近10年来HIV阳性孕产妇接受母婴阻断(PMTCT)的抗逆转录病毒治疗(ART)后18月龄幼儿体格发育不良的影响,为母婴阻断的ART用药方案提供科学依据。方法回顾性选取南宁市2010年1月至2019年12月接受PMTCT的ART用药的每年新报告HIV阳性孕产妇及其所生HIV阴性婴儿作为病例组(共1109例),通过国家PMTCT系统数据库收集分析其历史卡片和PMTCT资料。选取南宁市妇幼保健院2019年健康孕产妇所生的健康婴儿1778名为对照组,收集分析其18月龄幼儿的身高、体重和头围等健康体检资料,幼儿体格发育不良指这3项指标中至少1项低于正常值。结果病例组的HIV阳性孕产妇1112例,婴儿为1109例,孕产妇及婴儿接受PMTCT的ART用药比例分别为94.42%(1050/1112)和96.12%(1066/1109);18月龄幼儿的HIV阳性率为0.93%(7/755)、死亡率为0.99%(11/1109)、HIV母婴传播率为1.56%。病例组18月龄幼儿(755例)健康体检发现幼儿体格发育不良占17.22%(130/755);对照组18月龄幼儿(1778例)体格发育不良占9.84%(175/1778),两组差异具有统计学意义(P<0.001)。结论 HIV阳性母亲及其所生婴儿接受PMTCT的ART用药的18月龄幼儿体格发育潜在的不良影响,应引起高度关注。

关键词: 艾滋病病毒, 预防艾滋病母婴传播, 抗逆转录病毒用药, 18月龄幼儿, 体格发育

Abstract: Objective This retrospective study aims to analyze the adverse influence on physical development of 18-month-old children born by HIV-positive mothers who received anti-retroviral therapy (ART) for prevention mother-to-child transmission (PMTCT) of HIV in past 10 years in Nanning,so as to better tailor future PMTCT medication program for providing scientific evidences.Methods Participants were divided into case group and control group based on the design of retrospective case-control study.Samples (n=1109) of the case group were annually new reported HIV-positive mothers who received ART for PMTCT and their HIV-negative infants from January 2010 to 2019 December in Nanning city.History cards and PMTCT data of participants w were obtained through the national PMTCT database.The control group included healthy mothers and their healthy infants born in 2019 (n=1778) in Nanning Maternity and Child Health Hospital.Physical development data including height,weight and head circumference of 18-month-old infants were collected.Children whose physical examination results were below the range of normal value of at least one of the three aforementioned indicators were identified as physical dysplasia.Results There were 1112 HIV-positive mothers and 1109 infants in the case group,and ART rate of PMTCT for mothers was 94.42%（1050/1112）and 96.12%（1066/1109）for kids.Rates of HIV positive,mortality and mother-to-child transmission among these children aged 18 months were respectively 0.93% (7/755),0.99%（11/1109）and 1.56%.Physical examination results indicated 17.22% (130/755) of physical dysplasia among infants aged 18 months in the case group while 9.84% (175/1778) reported in the control group.The difference between the two group showed statistically significance (P<0.001).Conclusions Potential adverse influence from ART of PMTCT on physical development of 18-month-old infants born by HIV-positive mothers that should be highly attracted attention.

Key words: Human immunodeficiency virus, Prevent mother-to-child transmission of HIV, Antiretroviral treatment, Children aged 18 Months, Physical development

葛宪民, 朱金辉, 蒋武, 蓝光华, 唐驰, 李江恒, 林倩, 陈欢欢, 罗柳红, 李珊珊, 李彬, 温平镜, 黄玉满, 孟琴, 刘帅凤, 吴秀玲, 黄精华, 陆华湘, 邓月琴. 南宁市HIV阳性孕产妇接受母婴阻断治疗后18月龄幼儿体格发育不良10年回顾性研究[J]. 新发传染病电子杂志, 2020, 5(4): 243-248.

Ge Xianmin, Zhu Jinhui, Jiang Wu, Lan Guanghua, Tang Chi, Li Jiangheng, Lin Qian, Chen Huanhuan, Luo Liuhong, Li Shanshan, Li Bin, Wen Pingjing, Huang Yuman, Meng Qin, Liu Shuaifeng, Wu Xiuling, Huang Jinghua, Lu Huaxiang, Deng Yueqin. A10-year retrospective investigation on the physical development of children aged18months bore by HIV-positive mothers after receiving ART of prevention of mother-to-child transmission of HIV in Nanning[J]. Electronic Journal of Emerging Infectious Diseases, 2020, 5(4): 243-248.

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南宁市HIV阳性孕产妇接受母婴阻断治疗后18月龄幼儿体格发育不良10年回顾性研究

A10-year retrospective investigation on the physical development of children aged18months bore by HIV-positive mothers after receiving ART of prevention of mother-to-child transmission of HIV in Nanning

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