鼻腔鼻窦曲霉菌病103例病理学观察

doi:10.19871/j.cnki.xfcrbzz.2020.04.007

新发传染病电子杂志 ›› 2020, Vol. 5 ›› Issue (4): 249-252.doi: 10.19871/j.cnki.xfcrbzz.2020.04.007

鼻腔鼻窦曲霉菌病103例病理学观察

朱娅男¹, 刘德纯²

1.安徽省蚌埠市第三人民医院病理科,安徽蚌埠 233099;
2.安徽省蚌埠医学院病理学教研室,安徽蚌埠 233017

收稿日期:2020-05-15 出版日期:2020-11-30 发布日期:2020-12-31
通讯作者: 刘德纯,Email:ahbbldc@sina.com

Pathological observation of103cases with aspergillosis of the nasal, paranasal sinus

Zhu Yanan¹, Liu Dechun²

1. Department of Pathology,The Third People's Hospital of Bengbu City,Anhui Bengbu 233099,China;
2. Department of Pathology,Bengbu Medical College,Anhui Bengbu,233017,China

Received:2020-05-15 Online:2020-11-30 Published:2020-12-31

摘要/Abstract

摘要： 目的观察和分析鼻腔鼻窦曲霉菌病的病理形态特征,以加深认识,提高诊断水平。方法回顾性观察2012–2018年间收到的鼻腔鼻窦活检切片,并用过碘酸席夫染色(PAS)和六胺银染色(GMS)进一步验证,分析其病理特征。结果确认103例鼻腔鼻窦曲霉菌病,均为非浸润性,其中101例为曲霉菌球,2例为变应性曲霉菌病。曲霉菌球多数由菌丝缠绕交织呈团块状,部分呈分层状结构,并可见曲霉菌变性、坏死、钙化,伴炎细胞浸润。结论曲霉菌感染是鼻腔鼻窦真菌性炎症的重要原因,常形成曲霉菌球。特殊染色(PAS和GMS)有助于确认真菌形态。

关键词: 鼻腔鼻窦, 曲霉菌病, 病理学

Abstract: Objective To observe and analyze the pathological features of aspergillosis of nasal cavity and sinus in order to deepen the understanding and improve the diagnostic level.Methods The nasal cavity and sinus biopsy sections received by the department from 2012 to 2018 were reviewed retrospectively,and further verified by peroidic acid Schiff(PAS) staining and Grocott methenanine silver (GMS)staining to analyze their pathological characteristics.Results 103 cases of aspergillosis of the nasal cavity and sinus were confirmed to be non-invasive type,including 101 cases of aspergillusballs(aspergillomas)and 2 cases of allergic aspergillosis.Most aspergillus balls were clumped by mycelium(hyphae) winding and interweaving,and some were stratified,with aspergillus degeneration,necrosis and calcification,accompanied by inflammatory cell infiltration.Conclusions Aspergillus infection is an important cause of fungal rhinosinusitis with aspergilloma formation usually.Specific staining (PAS and GMS) may help to confirm fungal morphology.

Key words: Nasal cavity and sinus, Aspergillosis, Pathology

朱娅男, 刘德纯. 鼻腔鼻窦曲霉菌病103例病理学观察[J]. 新发传染病电子杂志, 2020, 5(4): 249-252.

Zhu Yanan, Liu Dechun. Pathological observation of103cases with aspergillosis of the nasal, paranasal sinus[J]. Electronic Journal of Emerging Infectious Diseases, 2020, 5(4): 249-252.

参考文献

[1] 中华医学会.临床技术操作规范-病理学分册[M],北京:人民军医出版社,2004:141-145.
[2] 武忠弼,杨光华.中华外科病理学[M].北京:人民卫生出版社,2002:2616.
[3] Sternberg SS.Diagnostic Surgical Pathology(3rd)(诊断外科病理学)[M].回允中主译,北京:北京大学医学出版社,2003:886.
[4] Kimura M.Histopathological diagnosis of fungal sinusitis and variety of its etiologic fungus[J].Med Mycol J,2017,58(4):J127-J132.
[5] Montone KT,Livolsi VA,Feldman MD,et al.Fungal rhinosinusitis:A retrospective microbiologic and pathologic review of 400 patients at a single university medical center[J].Int J Otolaryngol,2012,2012:684835.
[7] Thopson GR,Patterson TF.Fungal disease of the nose and paranasal sinuses[J].J Allergy Clin Immunol,2012,129(2):321-326.
[7] 刘铭,刘华超,韩德民.鼻及鼻窦的霉菌性疾病[J].耳鼻咽喉头颈外科,2000,7(4):252-256.
[8] 杨继洲.鼻及鼻窦曲霉菌病57例临床病理分析[J].医学信息,2010,5(3):525-526.
[9] 孙姸.真菌球性鼻窦炎的临床和病理特征观察[J].中国伤残医学,2014,22(5):147-148.
[10] 冯国红,胡亚玲,姜伟丽,等.鼻腔鼻窦曲菌病18例临床病理分析[J].包头医学,2012,36(1):19.
[11] 鲍玲,李素梅,宋昌湘.鼻腔与鼻窦曲霉菌病27例报告[J].临床耳鼻咽喉科杂志,1998,12(9):418.
[12] 黄志俊.非侵袭型鼻腔和鼻窦曲菌病19例报告[J].苏州医学院学报.1999,19(12):1352-1353 .
[13] 马莉.16例鼻腔鼻窦曲菌病临床特点及治疗[J].医药前沿,2014,35(12):133-134.
[14] 杨旭,雷科.98例真菌球型鼻窦炎的临床特点和鼻声反射分析[J].临床耳鼻咽喉头颈外科杂志,2011,25(17):783-785.
[15] Montone KT.Pathology of fungal rhinosinusitis:A review[J].Head Neck Pathol,2016,11(1):40-46.
[16] Agarwal R,Bansal S.Chakrabarti A.Are allergic fungal rhinosinusitis and allergic bronchopulmonary aspergillosis lifelong condition[J].Med Mycol,2017,55(1):87-95.
[17] Lass-Florl C.How to make fast diagnosis in invasive aspergillosis[J].Med Mycol,2019,57(Suppl.2):S155-S160.

鼻腔鼻窦曲霉菌病103例病理学观察

Pathological observation of103cases with aspergillosis of the nasal, paranasal sinus

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 3

编辑推荐

Metrics

本文评价

[1]	刘德纯, 李宏军. 艾滋病与艾滋病毒感染者48例临床影像与病理分析[J]. 新发传染病电子杂志, 2019, 4(3): 152-155.
[2]	郑秋婷, 董常峰, 陆普选, 陈晓芳, 罗婷婷, 乐晓华, 张芸, 刘俐. 彩色多普勒超声与多层螺旋CT扫描在颈部淋巴结结核诊断中的应用对比分析[J]. 新发传染病电子杂志, 2017, 2(4): 218-222.
[3]	张骜丹, 边杰, 罗佳文, 孙伟航. IgG4相关性涎腺炎的CT诊断价值[J]. 新发传染病电子杂志, 2017, 2(3): 175-178.