泛基因型DAA治疗慢性丙型肝炎

新发传染病电子杂志 ›› 2018, Vol. 3 ›› Issue (1): 30-33.

泛基因型DAA治疗慢性丙型肝炎

付小义¹, 金娴¹, 徐晓婧¹, 彭雁忠²

1.深圳市第七人民医院感染科,检验科,广东深圳 518081;
2.北京大学深圳医院感染科,广东深圳 518000

收稿日期:2017-11-19 出版日期:2018-02-28 发布日期:2020-06-29
通讯作者: 彭雁忠,Email：pyz988@163.com
基金资助:
深圳市科创委科技计划延伸项目（JCYJ20150402092102041）

Pan-genotype DAA for treatment of chronic hepatitis C

FU Xiao-yi¹, JIN Xian¹, XU Xiao-jing¹, PENG Yan-zhong²

1. Shenzhen Seventh People's Hospital Infectious diseases department, Clinical Laboratory,Guangdong Shenzhen 518081, China;
2. Peking University Shenzhen Hospital Infectious diseases department, Guangdong Shenzhen 518000, China

Received:2017-11-19 Online:2018-02-28 Published:2020-06-29

摘要/Abstract

摘要： 目的观察泛基因型DAA（sofosbuvir+velpatasvir）治疗慢性丙型肝炎的疗效及副作用。方法在患者知情同意的情况下,选择符合条件(符合抗病毒治疗条件的我院2015–2017年间的住院或门诊丙型肝炎患者)的患者46人为治疗组,选择同期46例干扰素治疗的慢性丙型肝炎患者为对照组,治疗组采用泛基因型DAA治疗,12周后停药,对照组采用短效干扰素联合利巴韦林治疗。对比观察他们的治疗效果和副作用,疗效比较采用χ²检验。结果治疗组与对照组于12周时HCV-RNA转阴率,分别为93.47%和50%,两组对比差异有统计学意义（χ²=115.565,P<0.001）,治疗组副作用少于对照组;同时治疗组内,基因1、2、3、6型的HCV-RNA转阴率分别为100%、100%、83.33%、100%。结论泛基因型DAA治疗慢性丙型肝炎疗效好,初步观察除基因3型外,其他均为100%,且副作用少,有待更大样本量的随机临床试验证实。

关键词: 慢性丙型肝炎, DAA, HCV-RNA, 疗效

Abstract: Objective To observe the therapeutic efficacy and side effects of pan-genotype DAA (sofosbuvir+velpatasvir) in the treatment of chronic hepatitis C. Methods After the informed consent was obtained from the patients, 46 cases of chronic hepatitis C that met our recruitment criteria and were inpatients or outpatients in our hospital from 2015 to 2017 were selected as the treatment group. Other 46 cases of chronic hepatitis C receiving interferon therapy were selected as the control group. The treatment group was treated with pan-genotype DAA for 12 weeks,while the control group received short-acting interferon combined with ribavirin. The therapeutic efficacy and side effects were then compared. The comparison of therapeutic efficacy ts was evaluated by Chi-square test. Results At week 12, the HCV-RNA negative rates of the treatment group and the control group were 93.47% and 50%, respectively, with the difference being statistically significant (χ²=115.565, P<0.001). The side effects of the treatment group were less than those of the control group. In the treatment group, the negative rates of HCV-RNA in gene type 1, 2, 3, 6 were 100%, 100%, 77.78%, and 100%, respectively. Conclusion In the treatment of chronic hepatitis C, pan-genotype DAA has a favorable curative effect and less side effects, with the negative conversion rates being 100% except for genotype 3. However, its therapeutic efficacy needs further prove by large scale randomized trial.

Key words: Chronic Hepatitis C, DAA, HCV-RNA, Therapeutic effects

付小义, 金娴, 徐晓婧, 彭雁忠. 泛基因型DAA治疗慢性丙型肝炎[J]. 新发传染病电子杂志, 2018, 3(1): 30-33.

FU Xiao-yi, JIN Xian, XU Xiao-jing, PENG Yan-zhong. Pan-genotype DAA for treatment of chronic hepatitis C[J]. Electronic Journal of Emerging Infectious Diseases, 2018, 3(1): 30-33.

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