新型冠状病毒奥密克戎变异株感染：普通型与无症状/轻型的临床特征比较分析及胸部CT表现

doi:10.19871/j.cnki.xfcrbzz.2022.02.002

新发传染病电子杂志 ›› 2022, Vol. 7 ›› Issue (2): 6-10.doi: 10.19871/j.cnki.xfcrbzz.2022.02.002

• 新型冠状病毒肺炎防治专题 • 上一篇下一篇

新型冠状病毒奥密克戎变异株感染：普通型与无症状/轻型的临床特征比较分析及胸部CT表现

刘文浩¹, 杨金荣², 陈一鑫³, 周昀³, 李银凤⁴, 云永兴³, 杨根东³, 黄华³

1.深圳市第三人民医院,南方科技大学第二附属医院放射介入科,广东深圳 518112;
2.深圳市第三人民医院,南方科技大学第二附属医院儿科广东深圳 518112;
3.深圳市第三人民医院,南方科技大学第二附属医院放射科,广东深圳 518112;
4.深圳市第三人民医院,南方科技大学第二附属医院感染科,广东深圳 518112

收稿日期:2022-03-22 出版日期:2022-05-31 发布日期:2022-07-07
通讯作者: 黄华,Email：hncz05hh@163.com
基金资助:
深圳市龙岗区科技发展资金项目（LGKCXGZX2020002）

SARS-CoV-2 omicron variant strains infection: comparative analysis of clinical features in moderate group and mild/asymptomatic group and chest CT findings

Liu Wenhao¹, Yang Jinrong², Chen Yixin³, Zhou Yun³, Li Yinfeng⁴, Yun Yongxing³, Yang Gendong³, Huang Hua³

1. Department of Interventional Radiology, The Third People's Hospital of Shenzhen, the Second Affiliated Hospital of Southern University of Science and Technology, Guangdong Shenzhen 518112;
2. Department of Pediatrics, The Third People's Hospital of Shenzhen, the Second Affiliated Hospital of Southern University of Science and Technology, Guangdong Shenzhen 518112;
3. Department of Radiology, The Third People's Hospital of Shenzhen, the Second Affiliated Hospital of Southern University of Science and Technology, Guangdong Shenzhen 518112;
4. Department of Infectious Diseases, The Third People's Hospital of Shenzhen, the Second Affiliated Hospital of Southern University of Science and Technology, Guangdong Shenzhen 518112

Received:2022-03-22 Online:2022-05-31 Published:2022-07-07

摘要/Abstract

摘要： 目的探讨新型冠状病毒奥密克戎变异株感染患者不同分型的临床特征差异及胸部CT影像表现。方法回顾性分析深圳市第三人民医院2022年1–2月收治的68例新型冠状病毒奥密克戎变异株感染患者临床资料,根据患者有无肺炎改变,将其分为普通型组和无症状/轻型组,比较两组间临床表现差异,分析普通型组胸部CT影像特点。结果 68例新型冠状病毒奥密克戎变异株感染者中,临床主要表现为咳嗽49例、咽部不适27例、发热24例、乏力12例,普通型组发热比例高于无症状/轻型组,差异有统计学意义（P<0.05）,普通型组合并基础疾病比例高于无症状/轻型组,差异有统计学意义（P<0.05）,普通型组红细胞沉降率峰值高于无症状/轻型组,差异有统计学意义（P<0.05）;病程中最低核酸Ct值在普通型组与无症状/轻型组中差异无统计学意义。普通型组患者胸部CT表现为胸膜下分布为主的磨玻璃影和实变影,肺炎病灶占全肺体积的占比平均为2.2%（0.1%~12.2%）,肺炎病灶达峰距离始发症状时间平均为8.6d。结论新型冠状病毒奥密克戎变异株感染患者临床症状轻,发热、合并基础疾病及红细胞沉降率可作为预警肺炎发生的观察指标。病毒对肺的损伤程度轻,胸部CT主要表现为磨玻璃影及实变影,病灶以胸膜下分布多见。

关键词: 新型冠状病毒肺炎, 新型冠状病毒, 胸部, 体层摄影术, X线计算机, 核酸, 人工智能

Abstract: Objective To investigate the differences of clinical characteristics in patients with SARS-CoV-2 omicron variant strains infection in different group and Chest CT imaging. Method A retrospective analysis of the clinical data of 68 patients with SARS-CoV-2 omicron variant infection was conducted. According to whether the patients had pneumonia or not, they were divided into moderate group and asymptomatic/mild group, the clinical manifestation differences between the two groups were compared, and the moderate group chest CT imaging characteristics were analyzed. Result Among the 68 cases of SARS-CoV-2 omicron variant infection, the main clinical manifestations were cough in 49 cases, pharyngeal discomfort in 27 cases, fever in 24 cases, and fatigue in 12 cases. The proportion of fever in the moderate group was higher than that in the asymptomatic/mild group, and the difference was statistically significant (P<0.05), the proportion of pre-existing diseases in the moderate group was higher than that of the asymptomatic/mild group, the difference was statistically significant (P<0.05), the peak ESR in the moderate group was higher than that of the asymptomatic/mild group, the difference was statistically significant (P<0.05), the difference of the lowest Ct value of nucleic acid was not statistically significant between the moderate group and asymptomatic/mild group. The common chest CT of omicron variant pneumonia was subpleural ground-glass opacity and consolidation. The percentage of pneumonia lesions to the whole lung volume showed an average of 2.2% (0.1%~12.2%) by chest CT. The average time from onset of symptoms to pneumonia peak is 8.6 days by chest CT. Conclusion The clinical symptoms of SARS-CoV-2 omicron variant infected patients are mild;fever, pre-existing diseases and ESR can be used as observation indicators. The damage to the lung by the virus is mild, and the chest CT mainly showed ground-glass opacity and consolidation with subpleural distribution.

Key words: Coronavirus disease 2019, Severe acute respiratory syndrome coronavirus 2, Chest, Radiography, X-ray, Nucleic acid, Artificial intelligence

刘文浩, 杨金荣, 陈一鑫, 周昀, 李银凤, 云永兴, 杨根东, 黄华. 新型冠状病毒奥密克戎变异株感染：普通型与无症状/轻型的临床特征比较分析及胸部CT表现[J]. 新发传染病电子杂志, 2022, 7(2): 6-10.

Liu Wenhao, Yang Jinrong, Chen Yixin, Zhou Yun, Li Yinfeng, Yun Yongxing, Yang Gendong, Huang Hua. SARS-CoV-2 omicron variant strains infection: comparative analysis of clinical features in moderate group and mild/asymptomatic group and chest CT findings[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(2): 6-10.

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新型冠状病毒奥密克戎变异株感染：普通型与无症状/轻型的临床特征比较分析及胸部CT表现

SARS-CoV-2 omicron variant strains infection: comparative analysis of clinical features in moderate group and mild/asymptomatic group and chest CT findings

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