HIV感染/AIDS患者焦虑和抑郁的研究进展

doi:10.19871/j.cnki.xfcrbzz.2022.03.018

摘要/Abstract

摘要： HIV感染/AIDS患者普遍存在严重的焦虑和抑郁,这些负性情绪不但会抑制HIV感染/AIDS患者的免疫功能,降低其生存质量及治疗依从性,而且是患者发生死亡的危险因素之一。因此,研究HIV感染/AIDS患者的焦虑和抑郁影响因素,帮助患者缓解负性情绪,提高患者的生存质量及治疗依从性显得尤为关键。近年来,国内外学者对HIV感染/AIDS患者焦虑和抑郁影响因素的认识不断深入,研究取得了一定进展,心理干预在HIV感染/AIDS患者的身心健康维护中起到了非常重要的作用。因此,作者系统回顾了HIV感染/AIDS患者焦虑和抑郁的相关文献,并着重综述了该人群焦虑和抑郁的影响因素和干预方式,以期为防治或缓解HIV感染/AIDS患者焦虑和抑郁提供依据。

关键词: 人类免疫缺陷病毒, 艾滋病, 焦虑, 抑郁, 综述

Abstract: HIV/AIDS patients generally have severe anxiety and depression,and these negative emotions will not only inhibit the immune function of HIV/AIDS patients,reduce the quality of their lives and treatment compliance,but also be one kind of the risk factors leading to death of patients.Therefore,it is particularly critical to study the influencing factors of anxiety and depression of HIV/AIDS patients,help them relieve negative emotions,and improve the quality of their lives and treatment compliance.In recent years,scholars at home and abroad have deepened their understanding of the influencing factors of anxiety and depression of HIV/AIDS patients,and made some progresses in this research filed.Many studies have shown that psychological intervention plays a very important role in the maintenance of physical and mental health of HIV/AIDS patients.Therefore, the author systematically reviewed the related researches on the anxiety and depression of HIV/AIDS patients,and emphatically summarized the influencing factors and intervention methods of anxiety and depression in this population,in order to provide evidence for preventing or relieving anxiety and depression of HIV/AIDS patients.

Key words: Human immunodeficiency virus, Acquired immune deficiency syndrome, Anxiety, Depression, Overview

何丁玲, 赵霞, 郭利华. HIV感染/AIDS患者焦虑和抑郁的研究进展[J]. 新发传染病电子杂志, 2022, 7(3): 84-89.

He Dingling, Zhao Xia, Guo Lihua. Research progress of anxiety and depression with HIV/AIDS patients[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(3): 84-89.

参考文献

[1] XIAO L, QI H, WANG YY, et al.The prevalence of depression in men who have sex with men(MSM)living with HIV:a meta-analysis of comparative and epidemiological studies[J]. Gen Hosp Psychiatry, 2020, 66:112-119.
[2] FEUILLET P, LERRT F, TRON L, et al.Prevalence of and factors associated with depression among people living with HIV in France[J]. HIV Med, 2017, 18(6):383-394.
[3] 祁慧,王敏,游霞,等. 男男性行为HIV/AIDS患者抑郁症及相关因素研究[J/CD]. 新发传染病电子杂志,2019,4(4):220-222,239.
[4] NGOCHO JS, WATT MH, MINJA L, et al.Depression and anxiety among pregnant women living with HIV in Kilimanjaro region,Tanzania[J]. PLoS One, 2019, 14(10):1-15.
[5] AGUS DF, EFFENDY E, CAMELLIA V.Screening of Anxiety and Depression Related CD4 Count of People Living with HIV/AIDS with Anti-Retroviral in Medan,Indonesia[J]. Open Access Maced J Med Sci, 2019, 7(16):2590-2594.
[6] 李宵, 刘洁. HIV感染者/AIDS患者抑郁研究进展[J]. 现代预防医学, 2019, 46(23):4368-4371.
[7] HENDRIKS T, SCHOTANUS D, HASSANKHAN M, et al.Resilience and well-being in the Caribbean:Findings from a randomized controlled trial of a culturally adapted multicomponent positive psychology intervention[J]. J Posi Psychol, 2020, 15(2):238-253.
[8] AMONOO HL, KURUKULASURIYA C, CHILSON K, et al.Improving quality of life in hematopoietic stem cell transplantation survivors through a positive psychology intervention[J]. Biol Blood Marrow Transplant, 2020, 26(6):1144-1153.
[9] 何丁玲, 冯世平, 赵霞, 等. 艾滋病住院患者焦虑和抑郁情况调查[J]. 预防医学, 2022, 34(2):166-170,175.
[10] CAMARA A, SOW MS, TOURÉ A, et al.Anxiety and depression among HIV patients of the infectious disease department of Conakry University Hospital in 2018[J]. Epidemiol Infect, 2020, 148(1):1-6.
[11] VASYLYEV M, DAVTYAN H, DENISIUK O, et al.Anxiety, depression and quality of life among HIV positive injection drug users in Ukraine,2017[J]. Infect Dev Ctries, 2019, 13(7.1):111S-117S.
[12] SALTERS KA, LRICK M, ANEMA A, et al.Harder-to-reach people living with HIV experiencing high prevalence of all-type mental health disorder diagnosis[J]. AIDS Care, 2017, 29(6):696-704.
[13] TESFAW G, AYANO G, AWOKE T, et al.Prevalence and correlates of depression and anxiety among patients with HIV on-follow up at Alert Hospital,Addis Ababa,Ethiopia[J]. BMC Psychiatry, 2016, 16(1):1-7.
[14] RANE MS, HONG T, GOVERE S, et al.Depression and Anxiety as Risk Factors for Delayed Care-Seeking Behavior in Human Immunodeficiency Virus-Infected Individuals in South Africa[J]. Clin Infect Dis, 2018, 67(9):1411-1418.
[15] LE TA, LE MQT, DANG AD, et al.Multi-level predictors of psychological problems among methadone maintenance treatment patients in difference types of settings in Vietnam[J]. Subst Abuse Treat Prev Policy, 2019, 14(1):1-10.
[16] THAI TT, JONES MK, HARRIS, et al. The association between symptoms of mental disorders and health risk behaviours in Vietnamese HIV positive outpatients:a cross-sectional study[J]. BMC Public Health, 2017, 17(1):1-12.
[17] 袁清青, 李芙蓉, 阮艺宏, 等. 国艾滋病患者群体中抑郁症患病率Meta分析[J]. 中国艾滋病性病, 2021, 27(1):45-49.
[18] 王丽娟, 林静静, 宋亮, 等. 北京市HIV/AIDS病人焦虑抑郁与社会支持状况及其相关性分析[J].中国艾滋病性病, 2019, 25(2):162-165.
[19] 冯理智, 郭朋乐, 何浩岚, 等. 广州市HIV/AIDS患者的抑郁、焦虑和睡眠障碍的临床分析[J]. 中国医师杂志, 2020, 22(4):481-485.
[20] 赵方, 李沙茜, 许六妹, 等. 深圳地区HIV-1感染人群焦虑和抑郁患病状况及相关因素[J]. 中国艾滋病性病, 2017, 23(12):1131-1134.
[21] 刘越男, 陆浩楠, 钟世勇, 等. 四川省凉山州HIV/AIDS患者污名化与焦虑抑郁的关系[J]. 中国艾滋病性病, 2021, 27(3):259-263.
[22] 肖永康, 徐增辉, 刘爱文, 等. 皖北地区中老年女性HIV/AIDS患者身体与心理健康状况调查[J].中华疾病控制杂志, 2021, 25(12):1398-1402.
[23] 赵玲, 蔡乐, 崔文龙, 等. 云南省HIV/AIDS病人抑郁和焦虑现状及影响因素分析[J]. 中国公共卫生, 2018, 34(1):85-88.
[24] 祁慧, 王敏, 江艳. 抑郁、焦虑情绪在HIV/AIDS患者中发病现状及影响因素研究[J]. 中国医师杂志, 2018, 20(6):839-843.
[25] ELBADAWI A, MIRGHANI H.Depression among HIV/AIDS Sudanese patients:a cross-sectional analytic study[J]. Pan Afr Med J, 2017, 30(26):1-8.
[26] 张彬, 余彬, 余军, 等. 四川省某艾滋病高流行县中老年HIV/AIDS病人心理健康状况及其影响因素分析[J]. 中国艾滋病性病, 2020, 26(6):622-624,647.
[27] GIANELLA S, SALONER R, CURTIN G, et al.A Cross-Sectional Study to Evaluate the Effects of Age and Duration of HIV Infection on Anxiety and Depression in Cisgender Men[J].AIDS Behav, 2022, 26(1):196-203.
[28] 谷家仪. 基于PERMA模式的积极心理学干预对艾滋病住院患者的应用研究[D]. 衡阳:南华大学, 2018.
[29] 黄江秀, 冯熙, 冯秀龙, 等. 艾滋病患者抑郁、焦虑等心理障碍及影响因素研究[J]. 齐齐哈尔医学院学报, 2020, 41(8):1043-1045.
[30] 陈学军, 李敏, 张丹, 等. 基层医院接受抗病毒治疗人类免疫缺陷病毒感染者抑郁焦虑状况及影响因素分析[J]. 实用医院临床杂志, 2020, 17(3):136-139.
[31] ELBADAWI A, MIRGHANI H.Depression among HIV/AIDS Sudanese patients:a cross-sectional analytic study[J]. Pan Afr Med J, 2017,26(1):1-8.
[32] AHMED A, SAQLAIN M, BASHIR N, et al.Health-related quality of life and its predictors among adults living with HIV/AIDS and receiving antiretroviral therapy in Pakistan[J]. Qual Life Res, 2021, 30(6):1653-1664.
[33] HELLMUTH J, COLBY D, VALCOUR V, et al.Depression and Anxiety are Common in Acute HIV Infection and Associate with Plasma Immune Activation[J].AIDS Behav, 2017, 21(11):3238-3246.
[34] DUKO B, GEJA E, ZEWUDE M, et al.Prevalence and associated factors of depression among patients with HIV/AIDS in Hawassa,Ethiopia,cross-sectional study[J]. Ann Gen Psychiatry, 2018, 17(1):1-6.
[35] 罗淑星, 周海龙, 周超, 等. 重庆市HIV阳性男男性行为者焦虑抑郁状况影响因素分析[J]. 预防医学情报杂志, 2021, 37(10):1371-1375,1381.
[36] YOUSUF A, MUSA R, ISA MLM, et al.Anxiety and Depression Among Women Living with HIV:Prevalence and Correlations[J]. Clin Pract Epidemiol Ment Health, 2020, 16: 59-66.
[37] PAPPIN M, WOUTERS E, BOOYSEN FL.Anxiety and depression amongst patients enrolled in a public sector antiretroviral treatment programme in South Africa:a cross-sectional study[J]. BMC Public Health, 2012, 12(1):1-9.
[38] TRAVAGLINI LE, HIMELHOCH SS, FANG LJ.HIV stigma and its relation to mental,physical and social health among black women living with HIV/AIDS[J]. AIDS Behav, 2018, 22(12):3783-3794.
[39] 中国疾病预防控制中心性病艾滋病预防控制中心. 国家免费艾滋病抗病毒药物治疗手册[M].4版.北京:人民出版社, 2019.
[40] DALWADI DA, OZUNA L, HARVEY BH, et al.Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs[J]. Pharmacol Rev, 2018, 70(3):684-711.
[41] 白少丽, 白若靖, 周莹荃, 等. 依非韦伦治疗后HIV感染/AIDS患者发生睡眠障碍和焦虑抑郁的影响因素[J]. 中国感染与化疗杂志, 2021, 21(4):399-405.
[42] 杜秀华, 杨绪红. 艾滋病患者抗病毒治疗中焦虑抑郁状态的分
析[J]. 中国继续医学教育, 2019, 11(6):104-106.
[43] XIAO YK, LIN CQ, LI L, et al.Individual and family level factors associated with physical and mental health-related quality of life among people living with HIV in rural China[J]. BMC Public Health, 2019, 19(1):1-7.
[44] 陈伟梅, 石义容, 苗琪琪, 等. HIV感染者治疗期间焦虑抑郁情况的纵向研究[J]. 中华护理杂志, 2019, 54(6):882-885.
[45] 孙朝霞, 杨谦, 赵利. 医务人员对HIV/AIDS病人歧视态度的研
究[J]. 中国性科学, 2019, 28(10):153-156.
[46] ZELIGMAN M, BARDEN SM.A narrative approach to supporting clients living with HIV[J]. J Constr Psychol, 2015, 28(1):67-82.
[47] 赵淑娴, 刘瑞华, 倪娇. 叙事心理治疗对艾滋病患者的影响[J].齐鲁护理杂志, 2019, 25(23):96-98.
[48] HOFMANN SG, ASMUNDSON GJ, BECK AT.The science of cognitive therapy[J]. Behav Ther, 2013, 44(2):199-212.
[49] HAN SY, HU Y, ZHU Z, et al.Dataset of cognitive behavioral intervention for persons living with HIV in China:a randomized pilot trial[J]. Data Brief, 2020, 30(1):1-9.
[50] TOBIN K, DAVEY-ROTHWELL MA, NONYANE BAS, et al.RCT of an integrated CBT-HIV intervention on depressive symptoms and HIV risk[J]. PLoS One, 2017, 12(12):1-12.
[51] PAULUS DJ, BRANDT CP, LEMAIRE C, et al.Trajectory of change in anxiety sensitivity in relation to anxiety,depression,and quality of life among persons living with HIV/AIDS following transdiagnostic cognitive-behavioral therapy[J]. Cogn Behav Ther, 2020, 49(2):149-163.
[52] 谢红燕, 陈鸿杰, 李冰, 等. 正念减压训练对HIV感染者/AIDS患者焦虑、抑郁情绪及免疫功能的影响[J]. 中国护理管理, 2019, 19(7):1058-1063.
[53] 程丽, 张玉娟, 胡健女, 等. 正念减压疗法在HIV感染孕妇中的应用效果研究[J]. 中国艾滋病性病, 2021, 27(12):1400-1403.
[54] MEDLEY A, KENNEDY C, O'REILLY K, et al. Effectiveness of peer education interventions for HIV prevention in developing countries:a systematic review and meta-analysis[J]. AIDS Educ Prev, 2009, 21(3):181-206.
[55] 汤淑爱, 边婕. 心理护理对艾滋病患者抗病毒治疗依从性的影
响[J]. 中国医药指南, 2019, 17(28):277.
[56] HE J, WANG Y, DU Z, et al.Peer education for HIV prevention among high-risk groups:a systematic review and meta-analysis[J]. BMC Infect Dis, 2020, 20(1):1-20.
[57] 李培培, 彭蕴丽, 王艺. 同伴教育联合心理护理对艾滋病患者服药依从性的影响[J]. 当代护士, 2019, 26(10):111-114.
[58] USLU GH.Influence of music therapy on the state of anxiety during radiotherapy[J].Turk J Oncol, 2017, 32(4): 141-147.
[59] 李幻, 唐素荣, 石柳春, 等. 音乐疗法改善HIV感染孕妇焦虑及抑郁情绪的临床观察[J]. 护理研究, 2013, 27(20):2138-2140.
[60] DUTHELY LM, SANCHEZ-COVARRUBIAS AP, MOHAMEDAB, et al. A multilingual,culturally competent mobile health intervention to improve treatment adherence among women living with HIV:protocol for a randomized controlled trial[J]. JMIR Res Protoc, 2020, 9(6):1-11.
[61] MOSKOWITZ J. Optimizing Resilience and Coping in HIV Via Internet Delivery(ORCHID)[EB/OL]. [2021-03-30].http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01997008.