人民卫生出版社系列期刊
ISSN 2096-2738 CN 11-9370/R

中国科技核心期刊（中国科技论文统计源期刊）
2020《中国学术期刊影响因子年报》统计源期刊

新发传染病电子杂志

新发传染病电子杂志 ›› 2023, Vol. 8 ›› Issue (1): 48-51.doi: 10.19871/j.cnki.xfcrbzz.2023.01.010

• 论著 • 上一篇    下一篇

1,25-二羟维生素D3水平与新生儿呼吸道感染分析研究

张辉1, 韩淑霞2, 张瑾1   

  1. 1.首都医科大学附属北京世纪坛医院产科,北京100038;
    2.北京嘉禾妇儿医院产科,北京 100068
  • 收稿日期:2021-03-21 出版日期:2023-02-28 发布日期:2023-03-30
  • 通讯作者: 张瑾,EMail：1483303071@qq.com
  • 基金资助:
    北京市海淀区卫生健康发展科研培育计划项目（HP2021-05-50602）

Correlation between 1,25-dihydroxyvitamin D3 level and neonatal respiratory tract infection

Zhang Hui1, Han Shuxia2, Zhang Jin1   

  1. 1. Department of Obstetrics, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
    2. Department of Obstetrics, Beijing Jiahe Women & Children's Hospital, Beijing 100068, China;
  • Received:2021-03-21 Online:2023-02-28 Published:2023-03-30

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摘要： 目的 探讨1,25-二羟维生素D3[1,25-(OH)2-D3]水平对新生儿呼吸道感染的影响,为新生儿呼吸道感染预防与治疗提供依据。方法 收集2020年1月至2020年6月在首都医科大学附属北京世纪坛医院新生儿重症监护病房诊断为急性呼吸道感染的新生儿120例作为呼吸道感染组,选择同期住院出生的116例健康足月新生儿作为对照组,同时测定各组新生儿血清1,25-(OH)2-D3水平。依据1,25-(OH)2-D3含量为四组,血清1,25-(OH)2-D3含量>250nmol/L为过量,血清1,25-(OH)2-D3含量75~250nmol/L为适宜,血清1,25-(OH)2-D3含量50~74nmol/L为不足,血清1,25-(OH)2-D3含量<50nmol/L为缺乏。结果 呼吸道感染组1,25-(OH)2-D3的水平显著低于对照组[P<0.001,（85.85±18.07）nmol/L比（119.34±26.12）nmol/L]。呼吸道感染组1,25-(OH)2-D3不足比例显著高于对照组（P<0.001）;而呼吸道感染组1,25-(OH)2-D3缺乏比例与对照组1,25-(OH)2-D3缺乏比例相比较,其差异无统计学意义（P>0.05）;重度呼吸道感染新生儿1,25-(OH)2-D3水平低于轻度呼吸道感染新生儿（P<0.05）。结论 呼吸道感染的新生儿1,25-(OH)2-D3水平显著低于正常健康新生儿。1,25-(OH)2-D3缺乏或出现不足均可能会导致新生儿感染呼吸道疾病,可适当补充维生素D以早期预防呼吸道感染。

关键词: 1, 25-二羟维生素D3, 新生儿, 呼吸道感染

Abstract: Objective To investigate the correlation between 1,25-(OH)2-D3 levels and neonatal respiratory tract infections, and to provide a basis for the prevention and treatment of neonatal respiratory tract infections. Method 120 neonates diagnosed with acute respiratory tract infection in the neonatal intensive care unit of Department of Obstetrics, Beijing Shijitan Hospital, Capital Medical University were selected as the respiratory tract infection group, 116 healthy neonates were selected as the control group in the same term, and the serum level of 1,25-(OH)2-D3 in each group was measured at the same time.They were divided into four groups according to the 1,25-(OH)2-D3 test level, 1,25-(OH)2-D3 >250nmol/L excessive, 1,25-(OH)2-D3 75-250nmol/L appropriate, 1,25-(OH)2-D3 50-74nmol/L deficient, and 1,25-(OH)2-D3 <50nmol/L deficient. Study data were analyzed using the IBM SPSS Statistics 24.0 statistical software. Result The level of 1,25-(OH)2-D3 in the respiratory tract infection group was significantly lower than that in the healthy control group [P<0.001, (85.85±18.07)nmol/L vs (119.34±26.12)nmol/L]. The proportion of 1,25-(OH)2-D3 deficiency in the respiratory tract infection group was significantly higher than that in the healthy control group (P<0.001). Compared with the proportion of 1,25-(OH)2-D3 deficiency, the difference was not statistically significant (P>0.05); the level of 1,25-(OH)2-D3 in the severe respiratory tract infection group was lower than that in the mild respiratory tract infection, and the difference was statistically significant Significance (P<0.05). Conclusion The level of 1,25-(OH)2-D3 in neonates with respiratory tract infection is significantly lower than that in normal healthy neonates. The lack or insufficiency of 1,25-(OH)2-D3 may lead to respiratory tract infection in neonates, vitamin D can be appropriately supplemented to prevent respiratory tract infection in the early stage.

Key words: 1, 25-dihydroxyvitamin D3, Neonate, Respiratory tract infection

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