肺结核患者肠道菌群失调的研究进展

doi:10.19871/j.cnki.xfcrbzz.2023.02.018

摘要/Abstract

摘要： 数以万亿计的微生物定植于人体肠道中,肠道菌群能通过衍生的代谢产物来保护宿主抵御疾病。在人类与结核分枝杆菌斗争的百余年历程中,肺结核已被证实会造成宿主的肠道菌群失调,影响菌群定植的耐药性,导致肺结核更难以治愈。本文概述了肠道菌群对肺部菌群的影响以及肺结核患者肠道菌群失调的最新研究进展。

关键词: 肺结核, 肠道菌群, 粪菌移植, 肺部菌群

Abstract: Trillions of microorganisms are planted in the human intestine, and gut microbiota can protect the host from disease through derived metabolites. During the thousands of years of struggle between human and Mycobacterium tuberculosis, pulmonary tuberculosis has been confirmed to cause the host's gut microbiota dysbiosis, affect resistance to the colonization of gut microbiota, and make pulmonary tuberculosis more difficult to cure. This article summarized the latest research progress of the pulmonary microbiome, the impact of gut microbiome on the pulmonary microbiome, and the gut microbiota dysbiosis in patients with pulmonary tuberculosis.

Key words: Pulmonary tuberculosis, Gut microbiota, Fecal microbiota transplantation, Lung microbiota

中图分类号:

杨舒琪, 李锋. 肺结核患者肠道菌群失调的研究进展[J]. 新发传染病电子杂志, 2023, 8(2): 82-85.

Yang Shuqi, Li Feng. Research progress on gut microbiota dysbiosis in patients with pulmonary tuberculosis[J]. Electronic Journal of Emerging Infectious Diseases, 2023, 8(2): 82-85.

参考文献

[1] WORLD HEALTH ORGANIZATION.Global tuberculosis report 2021[EB/OL]. [2021-10-14]. https://www.who.int/publications/digital/global-tuberculosis-report-2021.
[2] 卢春容,房宏霞,陆普选,等.2021 WHO全球结核病报告:全球与中国关键数据分析[J/CD].新发传染病电子杂志,2021,6(4):368-372.
[3] CUI X, GAO L, CAO B.Management of latent tuberculosis infection in China: Exploring solutions suitable for high-burden countries[J]. Int J Infect Dis, 2020, 92s: S37-s40.
[4] HONG BY, MAULéN NP, ADAMI AJ, et al. Microbiome Changes during Tuberculosis and Antituberculous Therapy[J]. Clin Microbiol Rev, 2016, 29(4): 915-926.
[5] GOSENS R, HIEMSTRA PS, ADCOCK IM, et al.Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease[J]. Eur Respir J, 2020, 56(2).
[6] 尤信信, 余卫业, 谭卫国, 等. 单细胞测序技术在结核病研究中的应用[J/CD]. 新发传染病电子杂志, 2017, 2(3): 151-154.
[7] JOHANSSON I, WITKOWSKA E, KAVEH B, et al.The Microbiome in Populations with a Low and High Prevalence of Caries[J]. J Dent Res, 2016, 95(1): 80-86.
[8] MATHIEU E, ESCRIBANO-VAZQUEZ U, DESCAMPS D, et al.Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma[J]. Front Physiol, 2018, 9: 1168.
[9] FERNáNDEZ-BARAT L, LÓPEZ-ALADID R, TORRES A. Reconsidering ventilator-associated pneumonia from a new dimension of the lung microbiome[J]. EBioMedicine, 2020, 60: 102995.
[10] BARCIK W, BOUTIN RCT, SOKOLOWSKA M, et al.The Role of Lung and Gut Microbiota in the Pathology of Asthma[J]. Immunity, 2020, 52(2): 241-255.
[11] TSAI YL, LIN TL, CHANG CJ, et al.Probiotics, prebiotics and amelioration of diseases[J]. J Biomed Sci, 2019, 26(1): 3.
[12] ARMSTRONG GL, MACCANNELL DR, TAYLOR J, et al.Pathogen Genomics in Public Health[J]. N Engl J Med, 2019, 381(26): 2569-2580.
[13] GOLLWITZER ES, MARSLAND BJ.Microbiota abnormalities in inflammatory airway diseases - Potential for therapy[J]. Pharmacol Ther, 2014, 141(1): 32-39.
[14] GRIER A, MCDAVID A, WANG B, et al.Neonatal gut and respiratory microbiota: coordinated development through time and space[J]. Microbiome, 2018, 6(1): 193.
[15] SHAH T, SHAH Z, BALOCH Z, et al.The role of microbiota in respiratory health and diseases, particularly in tuberculosis[J]. Biomed Pharmacother, 2021, 143: 112108.
[16] WYPYCH TP, WICKRAMASINGHE LC, MARSLAND BJ.The influence of the microbiome on respiratory health[J]. Nat Immunol, 2019, 20(10): 1279-1290.
[17] WANG H, YAO J, CHEN Y, et al. Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress [J]. (2222-1751 (Electronic)).
[18] KOH A, DE VADDER F, KOVATCHEVA-DATCHARY P, et al.From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites[J]. Cell, 2016, 165(6): 1332-1345.
[19] ANTUNES KH, FACHI JL, DE PAULA R, et al.Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response[J]. Nat Commun, 2019, 10(1): 3273.
[20] SEGAL LN, CLEMENTE JC, LI Y, et al. Anaerobic Bacterial Fermentation Products Increase Tuberculosis Risk in Antiretroviral-Drug-Treated HIV Patients [J]. Cell Host Microbe, 2017, 21(4): 530-537.e534.
[21] ERIBO OA, DU PLESSIS N, OZTURK M, et al.The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?[J]. Cell Mol Life Sci, 2020, 77(8): 1497-1509.
[22] HU Y, YANG Q, LIU B, et al.Gut microbiota associated with pulmonary tuberculosis and dysbiosis caused by anti-tuberculosis drugs[J]. J Infect, 2019, 78(4): 317-322.
[23] NAMASIVAYAM S, MAIGA M, YUAN W, et al.Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy[J]. Microbiome, 2017, 5(1): 71.
[24] PALMA ALBORNOZ SP, FRAGA-SILVA TFC, GEMBRE AF, et al.Obesity-Induced Dysbiosis Exacerbates IFN-γ Production and Pulmonary Inflammation in the Mycobacterium tuberculosis Infection[J]. Cells, 2021, 10(7):1732.
[25] BELL LCK, NOURSADEGHI M.Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection[J]. Nat Rev Microbiol, 2018, 16(2): 80-90.
[26] PEARL JE, DAS M, COOPER AM.Immunological roulette: Luck or something more? Considering the connections between host and environment in TB[J]. Cell Mol Immunol, 2018, 15(3): 226-232.
[27] SABEY KA, SONG SJ, JOLLES A, et al.Coinfection and infection duration shape how pathogens affect the African buffalo gut microbiota[J]. Isme j, 2021, 15(5): 1359-1371.
[28] MCHARDY IH, LI X, TONG M, et al.HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota[J]. Microbiome, 2013, 1(1): 26.
[29] 曹雨之, 王倩, 孟昱君, 等. 妊娠期糖尿病与肠道菌群改变的研究进展[J]. 中国临床新医学, 2022, 15(12): 1192-1197.
[30] GUPTA A, KHANNA S.Fecal Microbiota Transplantation[J]. Jama, 2017, 318(1): 102.
[31] OOIJEVAAR RE, TERVEER EM, VERSPAGET HW, et al.Clinical Application and Potential of Fecal Microbiota Transplantation[J]. Annu Rev Med, 2019, 70: 335-351.
[32] KHAN N, VIDYARTHI A, NADEEM S, et al.Alteration in the Gut Microbiota Provokes Susceptibility to Tuberculosis[J]. Front Immunol, 2016, 7: 529.
[33] WANG H, YAO J, CHEN Y, et al.Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress[J]. Emerg Microbes Infect, 2022, 11(1): 1806-1818.
[34] CUTHBERTSON L, WALKER AW, OLIVER AE, et al.Lung function and microbiota diversity in cystic fibrosis[J]. Microbiome, 2020, 8(1): 45.
[35] DICKSON RP, ERB-DOWNWARD JR, FALKOWSKI NR, et al.The Lung Microbiota of Healthy Mice Are Highly Variable, Cluster by Environment, and Reflect Variation in Baseline Lung Innate Immunity[J]. Am J Respir Crit Care Med, 2018, 198(4): 497-508.
[36] COSTELLO SP, HUGHES PA, WATERS O, et al.Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis: A Randomized Clinical Trial[J]. Jama, 2019, 321(2): 156-164.
[37] 中华人民共和国国家卫生和计划生育委员会. 肺结核诊断标准(WS 288—2017) [J/CD]. 新发传染病电子杂志, 2018, 3(1): 59-61.