登革热患者IgM/IgG抗体动力学及相关因素分析

新发传染病电子杂志 ›› 2018, Vol. 3 ›› Issue (2): 102-105.

登革热患者IgM/IgG抗体动力学及相关因素分析

赵令斋, 庾蕾, 洪文昕, 邱爽, 杨慧勤, 王建, 张复春

广州医科大学附属市八人民医院传染病研究所,广州 510060

收稿日期:2017-12-27 出版日期:2018-05-30 发布日期:2020-06-29
通讯作者: 张复春,Email: gz8hzfc@126.com
基金资助:
国家科技重大专项（2017ZX10305501）; 广州市健康医疗协同创新重大计划项目（201803040006）

Kinetics of dengue virus IgM/IgG antibodies and factor analysis in patients with dengue

ZHAO Ling-zhai, YU Lei, HONG Wen-xin, QIU Shuang, YANG Hui-qin, WANG Jian, ZHANG Fu-chun

Institute of Infectious Disease, Guangzhou Eighth People’s Hospital, Guangzhou 510060, China

Received:2017-12-27 Online:2018-05-30 Published:2020-06-29

摘要/Abstract

摘要： 目的了解我国登革热患者登革病毒IgM/IgG抗体动力学,分析免疫状态与疾病严重程度相关性。方法应用登革病毒IgM和IgG抗体捕获ELISA法动态检测1371例登革热患者登革病毒特异性IgM和IgG抗体,依据其水平判断患者的初次或二次感染状态。结果登革病毒IgM抗体水平随着病程进展迅速升高,至发病第6天阳性率即达95%以上,IgG抗体水平上升相对缓慢;初次感染与二次感染发生率分别为75.02%和24.98%;轻症和重症患者二次感染发生率无明显差别;老年患者二次感染发生率（52.79%）显著高于青壮年患者（18.39%）。结论我国登革热患者以初次感染为主,老年患者二次感染发生率高。

关键词: 登革热, 登革病毒, 二次感染, 抗体, 动力学

Abstract: Objective To investigate the kinetics of dengue virus IgM/IgG antibodies and to analyze the relationship between immune status and severity of dengue. Methods Dengue virus IgM-specific and IgG-specific antibodies in 1371 patients with dengue were detected using ELISA. Based on their levels, the primary or secondary infection was differentiated. Results The IgM antibody increased gradually with progression of the disease and the positive rate increased up to 95% at d 6 after onset of the disease. The IgG antibody increased more slowly. The incidences of primary and secondary infections of dengue were 75.02% and 24.98%, respectively. The incidence of secondary infection showed no significant difference between patients with mild and severe conditions. But the incidence of secondary infection was significantly higher in the elderly patients (52.79%) than the young and middle aged adult patients (18.39%). Conclusion sMost patients with dengue in China are diagnosed with primary infection. Higher incidence of secondary infection is observed in the elderly patients.

Key words: Dengue fever, Dengue virus, Secondary infection, Antibody, Kinetics

赵令斋, 庾蕾, 洪文昕, 邱爽, 杨慧勤, 王建, 张复春. 登革热患者IgM/IgG抗体动力学及相关因素分析[J]. 新发传染病电子杂志, 2018, 3(2): 102-105.

ZHAO Ling-zhai, YU Lei, HONG Wen-xin, QIU Shuang, YANG Hui-qin, WANG Jian, ZHANG Fu-chun. Kinetics of dengue virus IgM/IgG antibodies and factor analysis in patients with dengue[J]. Electronic Journal of Emerging Infectious Diseases, 2018, 3(2): 102-105.

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