光滑顶瓶梗霉感染引起脑脓肿1例

doi:10.19871/j.cnki.xfcrbzz.2024.01.011

新发传染病电子杂志 ›› 2024, Vol. 9 ›› Issue (1): 51-54.doi: 10.19871/j.cnki.xfcrbzz.2024.01.011

光滑顶瓶梗霉感染引起脑脓肿1例

黄赛林¹, 许绍强¹, 顾有明², 林勤剑³, 梁倩雯⁴, 向璇⁵, 叶娜芬⁶

1.广东三九脑科医院检验科,广东广州 510000;
2.广东三九脑科医院神经外科,广东广州 510000;
3.广东三九脑科医院药剂科, 广东广州 510000;
4.广东三九脑科医院影像科,广东广州 510000;
5.广东三九脑科医院病理科,广东广州 510000;
6.广州金域医学检验中心微生物室,广东广州 510000

收稿日期:2023-01-23 出版日期:2024-02-28 发布日期:2024-03-25
通讯作者: 黄赛林,Email：492153025@qq.com

A case of brain abscess caused by Acrophialophora levis infection

Huang Sailin¹, Xu Shaoqiang¹, Gu Youming², Lin Qinjian³, Liang Qianwen⁴, Xiang Xuan⁵, Ye Nafen⁶

1. Department of Laboratory, Guangdong Sanjiu Brain Hospital, Guangdong Guangzhou 510000, China;
2. Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangdong Guangzhou 510000, China;
3. Department of Pharmacy, Guangdong Sanjiu Brain Hospital, Guangdong Guangzhou 510000, China;
4. Department of Radiology, Guangdong Sanjiu Brain Hospital, Guangdong Guangzhou 510000, China;
5. Department of Pathology, Guangdong Sanjiu Brain Hospital, Guangzhou Guangdong 510000, China;
6. Department of Microbiology, Guangzhou Kingmed Center for Clinical Laboratory, Guangdong Guangzhou 510000, China

Received:2023-01-23 Online:2024-02-28 Published:2024-03-25

摘要/Abstract

摘要： 随着抗菌药物、抗癌药物、激素等的广泛应用和侵入性治疗技术的进步,侵袭性真菌感染的发病率和病死率逐年增加,一些罕见真菌越来越被认为具有临床致病性,已引起临床的重视。顶瓶梗属（Acrophialophora）真菌包含24个种,其中梭孢顶瓶梗霉（Acrophialophora fusispora）和光滑顶瓶梗霉（Acrophialophora levis）曾被报道具有临床致病性。光滑顶瓶梗霉感染引起脑脓肿罕见,目前临床最佳治疗手段尚不明确。本文通过分析广东三九脑科医院收治的1例光滑顶瓶梗霉感染引起脑脓肿患者的临床表现、影像学改变、病原学检查及诊疗过程,提高临床医生对侵袭性真菌感染引起脑脓肿感染的认识。

关键词: 脑脓肿, 顶瓶梗属, 光滑顶瓶梗霉, 侵袭性真菌感染

Abstract: With the wide application of antimicrobial drugs, anticancer drugs and hormones and the advancement of invasive treatment, the morbidity and mortality of invasive fungal infections have been increasing year by year, and some rare fungi have been increasingly recognized as clinically pathogenic, which has attracted clinical attention. The genus Acrophialophora contains 24 species, among which Acrophialophora fusispora and Acrophialophora levis have been reported to be clinically pathogenic. Brain abscesses caused by Acrophialophora levis infection are rare, and the optimal clinical treatment is still unclear. In this article, we analyze the clinical manifestations, imaging changes, pathogenetic examination, and diagnostic process of a patient with brain abscess caused by smooth telangiectasia infection admitted to our hospital, improving the awareness of invasive fungi causing infection with brain abscess.

Key words: Brain abscess, Acrophialophora, Acrophialophora levis, Invasive fungal infection

中图分类号:

R379

黄赛林, 许绍强, 顾有明, 林勤剑, 梁倩雯, 向璇, 叶娜芬. 光滑顶瓶梗霉感染引起脑脓肿1例[J]. 新发传染病电子杂志, 2024, 9(1): 51-54.

Huang Sailin, Xu Shaoqiang, Gu Youming, Lin Qinjian, Liang Qianwen, Xiang Xuan, Ye Nafen. A case of brain abscess caused by Acrophialophora levis infection[J]. Electronic Journal of Emerging Infectious Diseases, 2024, 9(1): 51-54.

参考文献

[1] 廖万清, 陈敏. 重要真菌病的临床诊治与防治策略[J/CD]. 新发传染病电子杂志, 2019, 4(4):196-199.
[2] LAN P, YANWEI Z, HAIYAN W, et al.Taxonomy and Phylogeny of Eight New Acrophialophora Species (Sordariales, Chaetomiaceae) from China[J]. J Fungi (Basel), 2023, 9(6):645.
[3] BHATTARU A, BLANCHARD I, KUNAMNENI S, et al.Acrophialophora: A Comprehensive Review of Clinical Guidelines and Diagnosis[J]. Cureus, 2023, 15(4):e37614.
[4] AL-MOHSEN IZ, SUTTON DA, SIGLER L, et al.Acrophialophora fusispora brain abscess in a child with acute lymphoblastic leukemia: review of cases and taxonomy[J]. J Clin Microbiol, 2000, 38(12):4569-4576.
[5] LI CW, LEE HC, CHANG TC, et al.Acrophialophora fusispora brain abscess in a patient with acquired immunodeficiency syndrome: a case report and review of the literature[J].Diagn Microbiol Infect Dis, 2013, 76(3):368-371.
[6] MODLIN CE, COLLINS LF, BURD EM, et al.Acrophialophora levis brain abscess in a kidney transplant patient: A case report and review of the literature[J]. Med Mycol Case Rep, 2020, 28:12-15.
[7] SANDOVAL-DENIS M, GENÉ J, SUTTON DA, et al.Acrophialophora, a Poorly Known Fungus with Clinical Significance[J]. J Clin Microbiol, 2015, 53(5):1549-1555.
[8] 中华医学会神经病学分会感染性疾病与脑脊液细胞学学组. 中枢神经系统感染性疾病的脑脊液宏基因组学第二代测序应用专家共识[J]. 中华神经科杂志, 2021, 54(12):1234-1240.
[9] 刘燕飞,陈思韵,李金卓.抗真菌药物联合治疗侵袭性真菌感染的研究进展[J].现代药物与临床, 2023, 38(1):229-233.
[10] YANG L,WANG C,ZHANG Y,et al.Central Nervous System Toxicity of Voriconazole: Risk Factors and Threshold - A Retrospective Cohort Study[J]. Infect Drug Resist, 2022,15:7475-7484.

光滑顶瓶梗霉感染引起脑脓肿1例

A case of brain abscess caused by Acrophialophora levis infection

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