关键词: 多重肺部感染, 艾滋病, 超声介入, 活检, 病理学, 病原体

Abstract: Objective To explore the application value of ultrasound-guided percutaneous lung biopsy(UGPLB) in the diagnosis of AIDS relate multiple microbial pulmonary infections(MMPI). Method The peripheral lung lesions of 257 AIDS patients with suspected MMPI in the Fourth People's Hospital of Nanning were selected to implement UGPLB from August 2012 to August 2023, and the obtained lung lesion samples were subjected to histopathological examination and pathogen detection. Result The success rate of UGPLB was 98.05%(252/257), 203 cases(80.56%) were finally diagnosed as MMPI, including 95 cases (37.70%) of Mycobacterium tuberculosis + fungus mixed infection, 77 cases (30.56%) of Mycobacterium tuberculosis + non-specific bacteria mixed infection, 16 cases (6.35%) of Klebsiella pneumoniae+fungus mixed infection, and 15 cases (5.95%) of Mycobacterium tuberculosis + Rhodococcus equi + fungus mixed infection; 49 cases (19.44%) had single pathogen pulmonary infection. There were 7 cases (2.72%) of complications after puncture, and all of them had mild symptoms. Conclusion The implementation of UGPLB to collect lung lesion specimens for patients with clinically suspected MMPI and peripheral lung lesions revealed by ultrasound has high success rate and low complication rate, helps to improve the diagnosis and differential diagnosis of MMPI.

Key words: Multiple microbial pulmonary infections, Acquired immune deficiency syndrome, Interventional ultrasound, Biopsy, Pathology, Pathogen