关键词: 女性, 宫颈病变, 人乳头状瘤病毒感染, 人乳头状瘤病毒基因分型, 病理特征

Abstract: Objective To analyze human papilloma virus (HPV) infection, genotypes distribution and pathological characteristics in the 120 female patients with cervical lesions. Method A retrospective analysis was performed on the clinical data of 120 female patients with cervical lesions in Qinhuangdao Maternal and Child Health Hospital between January 2019 and February 2024. All patients underwent pathological examination, HPV infection and genotypes detection to analyze HPV infection, genotypes distribution and pathological characteristics. Result In the 120 patients, incidence of HPV infection was 51.67% (62/120). Among the 62 infection patients, there were 34 cases (54.84%) with low-risk type and 28 cases (45.16%) with high-risk type. In low-risk HPV, incidence of HPV 6 genotype infection was the highest [35.48% (22/62)]. In high-risk HPV, incidence of HPV 16 and HPV 18 genotypes infection was the highest [17.74% (11/62), 12.90% (8/62)]. Pathological results showed that in the 120 patients, there were 48 cases (40.00%) with chronic inflammation, 34 cases (28.33%) with low-grade squamous intraepithelial lesions (LSIL), 30 cases (25.00%) with high-grade squamous intraepithelial lesions (HSIL) and 8 cases (6.67%) with cervical cancer (CC). There were significant differences in clinical symptoms, signs, HPV infection, viral load and distribution of HPV genotypes among patients with different pathological types (P<0.05). Conclusion The incidence of HPV infection is high in the 120 patients with cervical lesions, especially the incidence of HPV 6, HPV 16 and HPV 18 genotypes infection is higher. There are differences in clinical symptoms, signs, HPV infection, viral load and distribution of HPV genotypes among patients with different pathological types of cervical lesions. Clinically, targeted prevention measures can be formulated and implemented based on the above factors.

Key words: Female, Cervical lesion, HPV infection, HPV genotype, Pathological characteristic