血清sFlt-1、sCD163水平对重症支原体肺炎患者预后的预测价值

doi:10.19871/j.cnki.xfcrbzz.2024.04.008

摘要/Abstract

摘要： 目的探讨血清可溶性血管内皮生长因子受体1（soluble vascular endothelial growth factor receptor 1,sFlt-1）、可溶性血红蛋白清道夫受体163（soluble hemoglobin scavenger receptor 163,sCD163）在重症支原体肺炎（mycoplasma pneumonia,MPP）患者中的表达水平,分析其预测MPP预后的价值。方法选取2021年10月至2023年10月于齐齐哈尔市中医医院就诊的MPP患者249例（MPP组）作为研究对象,根据MPP患者病情严重程度,将患者分为轻症组145例与重症组104例,根据预后情况将104例重症组患者分为预后不良组30例与预后良好组74例。选取同期于本院体检健康者250例作为对照组。收集研究对象相关临床资料,酶联免疫吸附法（enzyme linked immunosorbent assay,ELISA）法检测血清sFlt-1、sCD163水平。多因素Logistic回归分析影响重症MPP患者预后的因素;受试者操作特征曲线（receiver operating characteristic curve,ROC曲线）分析血清sFlt-1、sCD163对重症MPP患者预后的预测价值。结果 MPP组患者血清sFlt-1、sCD163水平显著高于对照组（P<0.05）。重症组患者血清sFlt-1、sCD163水平显著高于轻症组（P<0.05）。预后不良组患者血清sFlt-1、sCD163、C反应蛋白（C reactive protein,CRP）水平显著高于预后良好组（P<0.05）。多因素Logistic回归分析结果显示,sFlt-1、sCD163是重症MPP患者发生预后不良的危险因素（P<0.05）。ROC曲线结果显示,血清sFlt-1、sCD163水平单独及联合预测重症MPP患者预后不良的AUC分别为0.846、0.854、0.923,且二者联合优于单独预测（Z=2.656、2.519,P<0.05）。结论血清sFlt-1、sCD163升高与重症MPP患者预后不良密切相关,且对患者预后不良有一定的预测价值。

关键词: 可溶性血管内皮生长因子受体1, 可溶性血红蛋白清道夫受体, 重症支原体肺炎, 预后

Abstract: Objective To investigate the expression levels of serum soluble vascular endothelial growth factor receptor 1 (sFlt-1) and soluble hemoglobin scavenger receptor (sCD163) levels in patients with severe mycoplasma pneumonia (MPP), and to analyze their value in predicting the prognosis of MPP. Method A total of 249 MPP patients (MPP group) who visited our hospital from October 2021 to October 2023 were collected as the study subjects, according to the severity of MPP patients' condition, they were separated into a mild illness group of 145 cases and a severe illness group of 104 cases, according to the prognosis, severe patients were grouped into a poor prognosis group of 30 cases and a good prognosis group of 74 cases. Clinical data related to the study subjects were collected, enzyme linked immunosorbent assay (ELISA) was applied to detect serum levels of sFlt-1 and sCD163. Multivariate Logistic regression was applied to analyze the factors affecting the prognosis of severe MPP patients. Receiver operating characteristic (ROC) curve was applied to analyze the predictive value of serum sFlt-1 and sCD163 for poor prognosis in severe MPP patients. Result The serum levels of sFlt-1 and sCD163 in the MPP group were obviously higher than those in the control group (P<0.05). The serum levels of sFlt-1 and sCD163 in the severe group were obviously higher than those in the mild group (P<0.05). The serum levels of sFlt-1, sCD163, and CRP in the poor prognosis group were obviously higher than those in the good prognosis group (P<0.05). The results of multivariate Logistic regression analysis showed that sFlt-1 and sCD163 were risk factors for poor prognosis in severe MPP patients (P<0.05). ROC curve results showed that the AUC of serum sFlt-1 and sCD163 levels alone and in combination in predicting poor prognosis in severe MPP patients was 0.846, 0.854, and 0.923, respectively, and the combination of the two was better than the single prediction (Z=2.656, 2.519, P<0.05). Conclusion Elevated serum sFlt-1 and sCD163 are closely related to poor prognosis in patients with severe MPP, and have certain predictive value for poor prognosis.

Key words: Soluble vascular endothelial growth factor receptor 1, Soluble hemoglobin scavenger receptor, Severe mycoplasma pneumonia, Prognosis

中图分类号:

R446.11+2

路兴中, 曹丹丹, 李明华, 陈丽英. 血清sFlt-1、sCD163水平对重症支原体肺炎患者预后的预测价值[J]. 新发传染病电子杂志, 2024, 9(4): 39-43.

Lu Xingzhong, Cao Dandan, Li Minghua, Chen Liying. Predictive value of serum sFlt-1 and sCD163 levels for the prognosis of patients with severe mycoplasma pneumonia[J]. Electronic Journal of Emerging Infectious Diseases, 2024, 9(4): 39-43.

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