关键词: 获得性免疫缺陷综合征, 淋巴瘤, 化学治疗, 预后因素, 回顾性研究

Abstract: Objective To analyze 29 clinical cases of AIDS-related lymphoma (ARL) admitted to Chongqing Public Health Medical Center during the period from 2015 to 2017. Methods The clinical data of 29 patients with ARL admitted to Chongqing Public Health Medical Center were analyzed retrospectively for the clinical features and the factors influencing their prognosis. The subjects were divided into the survival group and the death group. Their basic data and clinical symptoms were analyzed. Results A total of 29 patients were recruited as the subjects of the study, including 22 were males and 7 females. The mean age was (50.76±14.58) years, and the baseline CD4 cell count was (171.66±120.26)/μL. Fourteen cases showed fever with no known reason, 10 cases lymphadenopathy and 8 cases abdominal pain. Based on the pathological findings, 21 cases(72.41%) were diagnosed with B cell non-Hodgkin's lymphoma (NHL), 8 cases(27.59%) with T cell origin and Hodgkin lymphoma (HL), 4 cases at IPI score-related middle-risk and 25 cases at high-risk (86.21%). In total,15 cases(51.72%) had received highly active antiretroviral therapy (HAART) before their first presentation to our hospital or within one month after the diagnosis of lymphoma. And 11 cases (37.93％) received standard chemotherapy regimen formulated by the oncology specialists. Twenty-two cases of death occurred, with a mortality rate of 75.86%. Univariate analysis showed that prognostic factors included IPI score (OR=0.063, P<0.05) and standard chemotherapy (OR=20.4, P<0.05). Conclusion ARL is mainly B cell-originated NHL and it has various clinical manifestations. Most of the patients are already in their intermediate or advanced stage of lymphoma and the mortality rate is high. IPI score and standard chemotherapy regimen are the key to the prognosis of patients with ARL.

Key words: Acquired immunodeficiency syndrome, Lymphoma, Chemotherapy, Prognostic factors, Retrospective studies