美沙酮维持治疗的HIV感染者高效抗逆转录病毒治疗前后多药滥用情况调查研究

新发传染病电子杂志 ›› 2018, Vol. 3 ›› Issue (3): 175-177.

美沙酮维持治疗的HIV感染者高效抗逆转录病毒治疗前后多药滥用情况调查研究

梁纲¹, 吴锋耀², 阳初玉³, 李飞⁴, 陈万⁵, 王光彩²

1.广西医科大学,南宁 530021;
2.南宁市第四人民医院,南宁 530023;
3.广西壮族自治区江滨医院,南宁 530021;
4.南宁市公安局强制戒毒所,南宁530023;
5.广西壮族自治区人民医院,南宁 530021

收稿日期:2018-07-20 出版日期:2018-08-31 发布日期:2020-06-30
通讯作者: 吴锋耀,E-mail：wufengyao@126.com
基金资助:
2010年南宁市科学研究与技术开发计划项目（201003047C-3）; 南宁市青秀区科学与技术开发计划项目（2013S19）

Multidrug abuse in HIV-positive patients receiving methadone maintenance therapy before and after highly active antiretroviral therapy

LIANG Gang¹, WU Feng-yao², YANG Chu-yu³, LI Fei⁴, CHEN Wan⁵, WANG Guang-cai²

1. Guangxi Medical University, Guangxi Nanning 530021, China;
2. The Fourth People's Hospital of Nanning, Guangxi Nanning 530023, China;
3. The Guangxi Zhuang Autonomous Region riverside hospital, Guangxi Nanning 530021, China;
4. Compulsory detoxification center of Nanning Public Security Bureau, Guangxi Nanning 530023, China;
5. The Guangxi Zhuang Autonomous Region people's Hospital, Guangxi Nanning 530021, China

Received:2018-07-20 Online:2018-08-31 Published:2020-06-30

摘要/Abstract

摘要： 目的了解美沙酮维持治疗的HIV感染者在高效抗逆转录病毒治疗前后多药滥用情况。方法采用中国国家疾病控制中心制定的《接受抗病毒治疗的IDU患者情况调查表》对美沙酮维持治疗的HIV感染者入组前后进行问卷调查。结果美沙酮维持治疗的HIV感染者参加高效抗逆转录病毒治疗前并用的毒品按使用频度递减分别是为：海洛因、曲马多、安定、异丙嗪、麻谷;参加高效抗反转录病毒治疗后,海洛因、异丙嗪等毒品滥用的人数比率明显升高（P<0.05）;吸毒方式转向静脉吸毒为主,偷吸海洛因量较参加高效抗逆转录病毒治疗前有所升高,每月花费分别为( 103.24 ±36.17)元、( 370.16 ±87.25) 元。结论美沙酮维持治疗的HIV感染者仍存在海洛因、安定、曲马多等多药滥用现象,在进行抗逆转录病毒治疗后毒品滥用现象较前有所加剧,其对美沙酮维持治疗及抗逆转录病毒治疗的影响值得进一步研究。

关键词: 美沙酮维持治疗, HIV感染, 多药滥用

Abstract: Objective To understand the prevalence of multidrug abuse in HIV-positive patients receiving methadone maintenance therapy before and after highly active antiretroviral therapy (HAART). Methods A questionnaire survey was conducted in HIV-positive patients receiving methadone maintenance treatment before and after their administration of HAART. And the questionnaire, Survey of IDU Patients Receiving Anti-viral Therapy was developed by the National Center for Disease Control in China. Results The most frequently abused drug by HIV-positive patients who received methadone maintenance treatment before HAART was heroin, followed by tramadol, diazepam, promethazine, and mahgu. After receiving HAART, the percentage of subjects abusing heroin and promethazine increased significantly (P<0.05). The most common way of drug abuse turned to intravenous drug abuse, and the quantity of heroin abuse increased significantly after receiving HAART. The monthly cost on drug abuse was ￥(103.24 ±36.17) and (370.16±87.25), respectively before and after HAART therapy. Conclusion sIn HIV-positive patients who received methadone maintenance treatment, drug abuse, including heroin, diazepam, tramadol and other drugs, prevails. The drug abuse exacerbates after they receive HAART. The effects of drug abuse on methadone maintenance treatment and HAART need further study.

Key words: Methadone aintenancetreatment, HIV infection, multiple drug abuse

梁纲, 吴锋耀, 阳初玉, 李飞, 陈万, 王光彩. 美沙酮维持治疗的HIV感染者高效抗逆转录病毒治疗前后多药滥用情况调查研究[J]. 新发传染病电子杂志, 2018, 3(3): 175-177.

LIANG Gang, WU Feng-yao, YANG Chu-yu, LI Fei, CHEN Wan, WANG Guang-cai. Multidrug abuse in HIV-positive patients receiving methadone maintenance therapy before and after highly active antiretroviral therapy[J]. Electronic Journal of Emerging Infectious Diseases, 2018, 3(3): 175-177.

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