Abstract: Objective To provide evidence for developing scientific prevention and control strategies by analyzing the epidemic trends of tuberculosis bacteria resistant to Isoniazid(H),tuberculosis bacteria resistant to rifampicin(R),and multidrug-resistant situation in Shenzhen. Methods A total of 17 144 patients with smear-positive pulmonary tuberculosis were registered in Shenzhen during 1999-2015. Here were 16,846 strains identified as mycobacterium tuberculosis by cultured strain identification,which were used to analyze the epidemic trends of H,R,and multidrug-resistant situation. Results Among the 16,846 tuberculosis patients,2458(14.59%) cases had household registration and 14 388(85.41%) cases were floating population. The total multidrug-resistance rate was 4.14%(697/16,846),the initial multidrug-resistance rate and the acquired multidrug-resistance rate were 3.22%(509/15,793) and 17.85%(188/1053) respectively;70.69%(697/986) of H were multidrug-resistant tuberculosis in the 17 years. There were a downtrends in the frequentness of H and R,total multidrug-resistance rate and initial-resistance rate in the past 17 years(P<0.05). There was no down trend in the multidrug-resistance rate among the retreatment patients(P>0.05). Conclusion The floating population was the focus of tuberculosis prevention and control in Shenzhen. Totally,there was a down trend of multidrug-resistance rate in the past 17 years,but the multidrug-resistance rate among the retreatment patients was significantly higher than that among the untreated patients,and H were more likely to develop into multidrug-resistant tuberculosis. It is still needed to strengthen the TB control strategy,improve the quality of governance continuously,and curb the MDR-TB epidemic effectively.

Key words: Tuberculosis, Mycobacterium, Trends of drug resistance, Shenzhen city