Abstract: Objective Drug resistances of 3309 strains of Mycobacterium tuberculosis(MTB) were analyzed in Shenzhen to provide scientific evidence for the treatment planning of drug-resistant tuberculosis. Methods Clinically isolated culture-positive MTB obtained from Jan 2011 to Sep 2015 in Shenzhen Third People's Hospital were retrospectively studied.The bacterial type was identified as Mycobacterium tuberculosis complex. Susceptibility of the strains to antituberculosis drugs was tested. Statistical analyses were performed using the SPSS19.0. Differences of the distributions of the strains in various years were analyzed by χ2 test. Differences were considered as significant if P<0.05. Results The total drug resistance rate of the 3309 strains was about 34.90%,the multidrug-resistance(MDR) rate was about 12.06%,and the extensively drug-resistance(XDR) rate was about 2.33%. For both the sensitive strains and drug-resistance strains,there were significant differences between their distributions in different years(χ2=43.409、43.670,and P=0.000、0.000). No significant difference was found between the distributions of MDR group a in different years(χ2=5.531,P=0.237). Considering the drug-resistance degrees,isoniazid got the highest resistance rate of 19.64%,while protionamide got the lowest resistance rate of 2.18%. Conclusion The total drug resistance rate and MDR of tuberculosis patients in our hospital were both relatively high. Drug resistances should be paid enough attention to select reasonable therapeutic regimen for tuberculosis patients with drug resistant.

Key words: Tuberculosis, Mycobacterium tuberculosis, Multidrug-resistant tuberculosis, Extensively drug-resistant tuberculosis