Study of virtual touch tissue quantification and aspartate aminotransferase to platelet ratio for hepatic fibrosis in patients with Chronic Hepatitis B combined with nonalcoholic fatty liver

Abstract

Abstract: Objective To compare the diagnostic value of virtual touch tissue quantification (VTQ) and aspartate aminotransferase to platelet ratio index(APRI) for noninvasive assessment of hepatic fibrosis in patients with Chronic Hepatitis B combined with non-alcoholic fatty liver (NAFL). Methods One hundred and sixteen patients with HBV infection were recruited from May 2012 to May 2015 in our hospital.They were divided into the hepatic fibrosis group and hepatic fibrosis combined with NAFL group according to the pathological results, and all subjects were examined by VTQ and APRI systems.In addition, sex,age,and etc were also included as covariates. 39 healthy volunteers were selected as the control group, who accepted the same examinations. Results For the three groups results,there were statistical differences（P<0.05）in sex,age,BMI,thickness of soft tissue,oblique diameter of right lobe of liver(ODRL),thickness of spleen and APRI.The statistical difference of VTQ were significant (P<0.05)among these three groups by one-way analysis of variance(ANOVA), but there was no statistical difference in VTQ between the control group and the hepatic fibrosis combined with NAFL group（P>0.05） by covariance analysis correction.The difference of VTQ value and APRI between different pathological stages of hepatic fibrosis was statistically significant（P<0.001）, with the correlation coefficients of 0.721 and 0.618 respectively. Conclusions Compared with APRI ,VTQ is more accurate to evaluate hepatic fibrosis in patients without NAFL. VTQ provides better correlation with the pathological results, but when hepatic fibrosis combined with NAFL, VTQ can't truly reflect the presence of hepatic fibrosis.APRI is a better indicator in this situation.

Key words: Non-alcoholic fatty liver disease, Hepatic fibrosis, Virtual touch tissue quantification (VTQ), Aspartate aminotransferase to platelet ratio index(APRI)

LI Yu-dan, DONG Chang-feng, LIU Ying-xia, LI Han-ying, CHEN-Xin, LUO Yong-fang, HUANG Wei-qiang, LU Pu-xuan. Study of virtual touch tissue quantification and aspartate aminotransferase to platelet ratio for hepatic fibrosis in patients with Chronic Hepatitis B combined with nonalcoholic fatty liver[J]. Electronic Journal of Emerging Infectious Diseases, 2017, 2(2): 68-71.

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