Host-direct therapy for tuberculosis:opportunity and challenges

Abstract

Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is still one of the major causes of mortality worldwide. Despite the availability of effective antibiotics for tuberculosis (TB), 3%~9% patients relapse after receiving DOTS treatment. Furthermore, the spread of drug-resistant TB (DR-TB), expecially multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) makes it more difficult to cure. Novel drugs/strateges are urgently needed to arrest global transmission and prevent the uncontrolled development of MDR-TB. Unlike antibiotics and chemotherapy drugs, which directly kill Mtb, Host-directed therapy (HDT) enhances the host response against MTB infection to reduce excess inflammation, prevent tissue damage, repair damaged tissues and enhance the effectiveness of TB drug therapy. Therefore, HDT offers one potential solution to cure MDR-TB and improve the efficacy of anti-TB treatment.

Key words: Tuberculosis, Host-direct therapy, Drug resistance

CHEN Xin-chun, WEN Zhi-hua. Host-direct therapy for tuberculosis:opportunity and challenges[J]. Electronic Journal of Emerging Infectious Diseases, 2017, 2(3): 129-132.

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