Abstract: Objective To evaluate the efficacy of comprehensive Interventional therapy by bronchoscopy in the treatment of endobronchial tuberculosis(EBTB). Methods Two hundreds and thirty five patients with endobronchial tuberculosis were treated with bronchoscopy based comprehensive interventional therapy. These patients had no severe bronchostenosis and bronchomalacia. They were treated with localized frozen\microwave\clipping\balloon dilator\local medicine injection through bronchoscopy and received anti-tuberculosis treatment and aerosol inhalation. Clinical symptoms, bronchoscopy findings and CT imaging findings were compared to evaluate the efficacy. Results All the 235 patients underwent an average of 6 comprehensive treatments in the duration of six weeks. All patients benefited from the treatment as the clinical symptoms improved obviously. Most of the patients (194/235) had the lesion in trachea and bronchial disappeared, as well as the lung lesions absorbed. No obvious adverse reactions were observed during the comprehensive treatment. No bronchostenosis and EBTB relapse were observed in the 48 weeks’ follow-up. Conclusion The bronchoscopy-based comprehensive interventional therapy is effective and safe for treatment of endobronchial tuberculosis.

Key words: Bronchoscopy, Interventional therapy, Bronchial tuberculosis