Abstract: Objective The aim of this study was to survey the relationship between polymorphism of LTA4H gene and susceptibility to tuberculosis(TB)in Han nationality, and to screen functional SNP by incorporating withclinical data. Methods The single SNP site was detected by TaqMan probe technology. Polymorphism of susceptibility gene site was analyzed between 958 patients and 945 healthy controls. The relationship between polymorphism of LTA4H gene and susceptibility to tuberculosis in Han nationality was investigated. Results After analyzing the genotypic-frequency, CC in the patient groups was significantly higher than that of control groups(P<0.05)．Similarly, The C allele frequency in patient groups was significantly higher than that of control groups (χ²=6.20 P=0.0064). Conclusion The LTA4H gene polymorphism site rs17525495 may be associated with susceptibility to TB. Although rs17525495 may not be a functional SNP site, allele T may be responsible for protection.

Key words: Tuberculosis, TaqMan probe, Genotyping, SNPs