Abstract: Objective To analysis of the correlation between enterovirus and EB virus co-infection in children. Method A total of 275 infants and young children with HFMD were collected from 2010 to 2014 in Fenghua people's Hospital, including 186 throat swabs and 89 plasma samples. At the same time, control group samples from a total of 165 cases, including 144 throat swabs and 121 plasma samples) were collected from the same age children, in the hospital who were clinically diagnosed with respiratory tract infection (including upper respiratory tract infection, tonsillitis, pharyngitis, pneumonia and septicemia). Difference in the proportion of EBV infection in the two groups of children was compared. Results It found that the detection rate of EBV DNA in throat swab or plasma of children with hand-foot-and-mouth disease group was significantly higher than that of control group, which reached about 32.8% and 14.6% respectively. Conclusion There is a high degree of EBV infection in children who were infected with enterovirus. It is suggested that the co-infection of EB virus and human enterovirus in children with hand-foot-and-mouth disease deserves attentions.

Key words: Hand-foot-and-mouth disease, EB virus, Enterovirus