Abstract: Objective To investigate whether chest CT scan parameters have any association with CD4+T cell counts in severely immunocompromised patients coinfected with human immunodeficiency virus (HIV) and tuberculosis (TB). Methods This was a retrospective study and we collected and analyzed the clinical data and chest CT scan Results of HIV/TB coinfected patients admitted between January 2017 and December 2017. Results 118 patients coinfected with HIV and TB were included, and 116 patients had CD4⁺T cell counts less than 200 cells/μl. There are multiple lobar lesions in HIV/TB patients, and the average numbers of mediastinal lymph nodes、the maximum diameter of lymph nodes were larger in patients ofHIV/TB (P < 0.05). Exudation, nodules and miliary lesion were more common in patients of HIV/TB (P < 0.05). No significant differences ware observed in chest CT of patients with severe immunodeficiency (CD4⁺T cells < 200/μL), except that the maximum diameter of mediastinal lymph node in patients with CD4⁺T cell count less than 100/uL is larger than that in patients with CD4⁺T cell count more than 100/μL, (P < 0.005). Conclusion There are no significantly noticeable differences in chest CT scan parameters between patients with lower and higher CD4⁺T cell counts when their CD4⁺T cell counts are less than 200 cells/μl, except that the enlargement of mediastinal and hilar lymph nodes is more recognizable in patient with CD4⁺T cell counts less than 100 cells/μl.

Key words: Human immunodeficiency virus, Tuberculosis, CD4⁺T cell counts, Chest CT scan