Abstract: Objective To analyze the clinical recognition of talaromyces marneffei infection complications in an HIV-negative patient with lung cancer in clinical manifestations, diagnosis and treatment. Methods The clinical manifestations, pathological characteristic, imaging manifestations, diagnosis, the therapy and review of literature of a patient with talaromyces marneffei infection complications in an HIV-negative patient with lung cancer were presented. Results The HIV-negative patient was a 52-year-old male, with cough, expectoration, dyspnea and wasting as the main symptom. Themicrobes of sputum culture were Talaromyces marneffei. The pulmonary nodule in the right upper lobe was pathologically confirmed as lung adenocarcinoma.Combined with the clinical symptoms, the patient was diagnosed as lung adenocarcinoma with Talaromycosis marneffei. Conclusion Patients with non-HIV immunocompromised are high-risk groups of Marneffeinosis, which are clinically lack of characteristics. It can cause multiple organ damages and is easy to be misdiagnosed. For patients with life history in epidemic areas or immunocompromised patients, they should be alert to whether it is Talaromyces marneffei infection and make diagnosis and treatment as soon as possible.

Key words: Lung cancer, Talaromyces marneffei, Non-HIV