Abstract: Objective To investigate the clinical manifestations, chest imaging features, diagnosis and treatment of AIDS combined with Penicillium marneffei pneumonia. MethodWe retrospectively analyzed the clinical data of 25 patients diagnosed with AIDS combined with Penicillium marneffei pneumonia. ResultAmong the 25 patients, 20 were male and 5 were female, aged 28-64 years old, with an average age of (44±11) years old. The duration of disease ranged from 1 to 12 weeks, with a median duration of 4 weeks. Clinical manifestations of fever, cough, sputum, weight loss, shortness of breath, night sweats, abdominal pain, diarrhea, liver, spleen and lymph nodes, umbilical concave rash. CD4⁺T lymphocytes <50 /μl were present in 92% of patients with abnormal blood system. The chest imaging features are diverse, including patch, nodules, ground glass, cavity, mass, millimeter, mediastinum hilar lymph node enlargement, pleural effusion, pericardial effusion, etc. 84% of the patients also had other pulmonary infections. Twenty-two patients received amphotericin B and itraconazole for antifungal treatment, and 23 received anti-hiv treatment.Finally, 21 patients got better, 2 were discharged automatically, and 2 died. Conclusion The clinical and chest imaging manifestations of AIDS complicated with marneffei basilar pneumonia are complex and diverse.

Key words: AIDS, Penicillium marneffei pneumonia, Clinical analysis, Iconography