Research on antiviral progress of interferon-induced transmembrane protein

Abstract

Abstract: Interferon (IFN),binding to celluar interferon receptor specifically after stimulation, can promote the expression of hundreds of interferon stimulated genes (ISGs) that encodes many antiviral innate immune effectors,thus stimulating or regulating the host's immune response. And interferon-induced transmembrane protein (IFITM) , an important immune molecule, is just one of ISGs expression products. IFITM have multiple biological functions, such as antiviral infection, involving in tumor formation ,regulating bone metabolism, adjusting cell adhesion, affecting cell differentiation, and even having a role in cell signal transduction.However,The antiviral effect of IFITM is one of hot spots in current research.Not only can IFITM prevent the invasion of the virus through a variety of ways, but also the genetic polymorphism of IFITM has a certain correlation with the susceptibility and severity of the virus.Here we reviewed the antiviral progress of IFITM.

Key words: Interferon-induced transmembrane protein, Antiviral, Gene polymorphism

Li Haomin, Wu Shipin. Research on antiviral progress of interferon-induced transmembrane protein[J]. Electronic Journal of Emerging Infectious Diseases, 2020, 5(2): 122-125.

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