Human immunodeficiency virus-associated cryptococcal immune reconstitution inflammatory syndrome

Abstract

Abstract: Cryptococcal immune reconstitution inflammatory syndrome(C-IRIS) in human immunodeficiency virus (HIV)- infected patients manifests as a clinical worsening or new presentation of cryptococcal disease after initiating anti-retroviral therapy (ART). This review will discuss the clinical features, immunopathogenesis and management of this syndrome.

Key words: Human immunodeficiency virus, Acquired immune deficiency syndrome, Cryptococcal, Immune reconstitution inflammatory syndrome

Hu Zhiliang, Xu Chuanjun. Human immunodeficiency virus-associated cryptococcal immune reconstitution inflammatory syndrome[J]. Electronic Journal of Emerging Infectious Diseases, 2020, 5(2): 126-130.

References

[1] Okoye AA, Picker LJ.CD4+ T-cell depletion in HIV infection: mechanisms of immunological failure[J]. Immunol Rev, 2013, 254(1):54-64.
[2] 胡志亮, 陈伟, 陈亚玲, 等.人类免疫缺陷病毒感染者血清隐球菌抗原的筛查及相关隐球菌病变的分析[J]. 中华传染病杂志, 2018, 36(8):480-484.
[3] Rajasingham R, Smith RM, Park BJ, et al.Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis[J]. Lancet Infect Dis, 2017, 17(8):873-881.
[4] Migone C, Ford N, Garner P, et al. Updating guidance for preventing and treating cryptococcal disease: how evidence and decisions interface[J]. Coch Data System Rev, 2018, 11(11):ED000130.
[5] Longley N, Harrison TS, Jarvis JN.Cryptococcal immune reconstitution inflammatory syndrome[J]. Curr Opin Infect Dis, 2013, 26(1):26-34.
[6] Chang CC, Dorasamy AA, Gosnell BI, et al.Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome[J]. Aids, 2013, 27(13):2089-2099.
[7] Jarvis JN, Bicanic T, Loyse A, et al.Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes[J]. Clin Infect Dis, 2014, 58(5):736-745.
[8] Boulware DR, Meya DB, Bergemann TL, et al.Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study[J]. PLoS Med, 2010, 7(12):e1000384
[9] Haddow LJ, Colebunders R, Meintjes G, et al.Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions[J]. Lancet Infect Dis, 2010, 10(11):791-802.
[10] Hashimoto H, Hatakeyama S, Yotsuyanagi H .Development of cryptococcal immune reconstitution inflammatory syndrome 41 months after the initiation of antiretroviral therapy in an AIDS patient[J]. AIDS Res Therapy, 2015, 12(1):33.
[11] Longley N, Harrison TS, Jarvis JN.Cryptococcal immune reconstitution inflammatory syndrome[J]. Curr Opin Infect Dis, 2013, 26(1):26-34.
[12] 许传军, 胡志亮, 魏洪霞, 等.艾滋病患者中枢神经系统隐球菌感染的磁共振成像特征[J]. 中南大学学报: 医学版, 2017, 42(10):1184-1190.
[13] Hu Z, Wei H, Meng F, et al.Recurrent cryptococcal immune reconstitution inflammatory syndrome in an HIV-infected patient after anti-retroviral therapy: a case report[J]. Ann Clin Microbiol Antimicrob, 2013, 12(1):40.
[14] 孙丙虎, 胡志亮, 池云, 等. 艾滋病合并隐球菌相关免疫重建炎症综合征一例[J]. 中华传染病杂志, 2017,35(7):433-434.
[15] 胡志亮,陈伟,陈亚玲,等. 沙利度胺治疗艾滋病合并激素依赖性隐球菌免疫重建炎症综合征一例[J]. 中华传染病杂志, 2019, 37(7):438-440.
[16] Rohatgi S, Pirofski L-a.Host immunity to Cryptococcus neoformans[J]. Future Microbiol, 2015, 10(4):565-581.
[17] Meya DB, Manabe YC, Castelnuovo B, et al.Cost-effectiveness of serum cryptococcal antigen screening to prevent deaths among HIV-infected persons with a CD4+ cell count < or = 100 cells/microL who start HIV therapy in resource-limited settings[J]. Clin Infect Dis, 2010, 51(4):448-455.
[18] Shelburne SA 3rd, Darcourt J, White AC, Jr, et al. The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy[J]. Clin Infect Dis, 2005, 40(7):1049-1052.
[19] Sungkanuparph S, Filler SG, Chetchotisakd P, et al.Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study[J]. Clin Infect Dis, 2009, 49(6):931-934.
[20] Boulware DR, Bonham SC, Meya DB, et al.Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome[J]. J Infect Dis, 2010, 202(6):962-970.
[21] Yoon HA, Nakouzi A, Chang CC, et al.Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome[J]. J Infect Dis, 2019, 219(3):420-428.
[22] Chang CC, Omarjee S, Lim A, et al.Chemokine levels and chemokine receptor expression in the blood and the cerebrospinal fluid of HIV-infected patients with cryptococcal meningitis and cryptococcosis-associated immune reconstitution inflammatory syndrome[J]. J Infect Dis, 2013, 208(10):1604-1612.
[23] Jarvis JN, Meintjes G, Bicanic T, et al.Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis[J]. PLoS Pathog, 2015, 11(4):e1004754.
[24] Meya DB, Manabe YC, Boulware DR, et al.The Immunopathogenesis of Cryptococcal Immune Reconstitution Inflammatory Syndrome-Understanding a Conundrum[J]. Curr Opin Infect Dis, 2016, 29(1):10-22.
[25] Meya DB, Okurut S, Zziwa G, et al.Cellular immune activation in cerebrospinal fluid from ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome[J]. J Infect Dis, 2015, 211(10): 1597-1606.
[26] Meya D, Okurut S, Zziwa G, et al.Monocyte Phenotype and IFN-γ-Inducible Cytokine responses are associated with Cryptococcal immune reconstitution inflammatory syndrome[J]. J Fungi (Basel), 2017, 3(2):28.
[27] Sitapati AM, Kao CL, Cachay ER, et al.Treatment of HIV-related inflammatory cerebral cryptococcoma with adalimumab[J]. Clin Infect Dis, 2010, 50(2):e7-10.
[28] Meya DB, Okurut S, Zziwa G, et al.HIV-Associated Cryptococcal Immune Reconstitution Inflammatory Syndrome Is Associated with Aberrant T Cell Function and Increased Cytokine Responses[J]. J Fungi (Basel) , 2019, 5(2):42.
[29] Fourcade C, Mauboussin JM, Lechiche C, et al.Thalidomide in the treatment of immune reconstitution inflammatory syndrome in HIV patients with neurological tuberculosis[J]. AIDS Patient Care STDS, 2014, 28(11):567-569.
[30] Scriven JE, Rhein J, Hullsiek KH, et al.Early ART After Cryptococcal Meningitis Is Associated With Cerebrospinal Fluid Pleocytosis and Macrophage Activation in a Multisite Randomized Trial[J]. J Infect Dis, 2015, 212(5):769-778.
[31] Boulware DR, Meya DB, Muzoora C, et al.Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis[J]. N Engl J Med, 2014, 370(26):2487-2498.
[32] 中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心. 中国艾滋病诊疗指南(2018 版)[J]. 新发传染病电子杂志, 2019, 4(2):65-84.