Correlation between relative enhancement rate of Gd-EOB-DTPA enhanced MRI and liver function

doi:10.19871/j.cnki.xfcrbzz.2021.02.003

Abstract

Abstract: Objective To investigate the correlation between liver parenchyma uptake of gadoxetic acid disodium (Gd-EOB-DTPA) and Child-Pugh score and quantitative indexes. Methods The imaging data of patients hospitalized for hepatitis B cirrhosis in Beijing Ditan Hospital Affiliated to Capital Medical University from June 12, 2019 to December 12, 2019 and undergoing Gd-EOB-DTPA enhanced magnetic resonance examination were retrospectively analyzed. A total of 65 patients were enrolled and divided into 4 groups according to Child-Pugh score: normal group (score<5), group A (score 5~6), group B (score 7~9) and group C (score 10~15). The relative enhancement rates (RE_10min, RE_15min and RE_20min) were compared between the groups respectively. The multi-stage relative enhancement rates in each group were compared in pairs. Pearson correlation analysis was used to evaluate the correlation between RE_20min and Child-Pugh score and quantitative indexes. Results There was no statistical difference between normal group and group A (RE_10min, RE_15min and RE_20min) at the same time. There were statistical differences (RE_10min, RE_15min and RE_20min) between normal group and group B, normal group and group C, group A and group B, group A and group C at the same time (P<0.05). There was no significant difference (RE_10min, RE_15min and RE_20min) between group B and group C. RE_10min, RE_15min and RE_20min in the normal group, group A, group B, group C in the comparison between the two groups did not show statistical difference; RE_20min was negatively correlated with serum total bilirubin, prothrombin time and Child-Pugh score (r=-0.491,-0.481,-0.619, respectively, P<0.05). There was a positive correlation between RE_20min and serum albumin (r=0.352, P<0.05); with RE_20min (0.445) as the threshold value, the sensitivity and specificity for diagnosing normal liver function + Child-Pugh A grade are the highest, 89.2% and 64.3%, respectively, and the area under ROC curve is 0.813. Conclusions the degree of uptake of disodium gadolinium acid in liver parenchyma can quantitatively evaluate liver function and judge the reserve and prognosis of liver function in patients with liver cirrhosis.

Key words: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid, Liver function, Magnetic resonance imaging, Signal intensity

Zhou An, Lyu Zhibin, Du Yanni, Guan Chunshuang, Chen Budong, Xie Ruming. Correlation between relative enhancement rate of Gd-EOB-DTPA enhanced MRI and liver function[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(2): 88-91.

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