Distribution and drug resistance of pathogens with senile infectious diseases in intensive care unit

doi:10.19871/j.cnki.xfcrbzz.2021.02.005

Abstract

Abstract: Objective To analyze the distribution and drug resistance of pathogens in elderly patients with infectious diseases in intensive care unit (ICU), and to improve the clinical control of infection in senile patients in ICU. Methods The pathogen distribution and drug resistance of 300 senile patients with infectious diseases treated in the intensive care unit of Ziyang people's Hospital from January 2016 to December 2018 were retrospectively analyzed. Results A total of 511 specimens were isolated from a total of 468 pathogenic strains, which mainly originated from sputum (51.50%), followed by blood (19.02%), urine (16.24%), and pharyngeal swabs (13.25%), which contained 182 Glan-positive strains (38.89%), 232 Glan-negative strains ( 49.57%), and 54 strains of fungi (11.54%). Staphylococcus aureus and Staphylococcus hemolyticus showed high resistance to penicillin, erythromycin, and gentamicin; resistance to vancomycin was the lowest. Escherichia coli were highly resistant to piperacillin, levofloxacin, and cotrimoxazole, with resistance rates >60%. Klebsiella pneumoniae is highly resistant to piperacillin, cefoxitin, and cotrimoxazole, with a resistance rate of >60%. Acinetobacter baumannii is sensitive to polymyxin E and has a high resistance rate to other antibiotics. Candida albicans was less resistant to voriconazole, 5-fluorocytosine, fluconazole and itraconazole, while Candida tropicalis was less resistant to 5-fluorocytosine. Conclusions The main pathogens of ICU infection in our hospital are conditional pathogens, mainly Gram-negative bacteria, and the drug resistance is serious. The distribution and drug resistance of pathogens should be detected regularly in clinic to provide basis for rational use of antibiotics.

Key words: Intensive care unit, Infectious diseases, Pathogens, Drug resistance

Liang Zhuangwan, Zhang Qun, Jiang Qiuyan, Du Lijun. Distribution and drug resistance of pathogens with senile infectious diseases in intensive care unit[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(2): 97-100.

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