Combination of procalcitonin,prealbumin and percentage of neutrophils for the diagnosis of bacterial infectious enteritis in children

doi:10.19871/j.cnki.xfcrbzz.2021.02.008

Abstract

Abstract: Objective To investigate the diagnostic value of procalcitonin (PCT), proalbumin (PA) combined with percentage of neutrophils (NP) in children with bacterial infectious enteritis, in order to provide theoretical basis for clinical diagnosis and treatment of such patients. Methods Retrospective analysis of 107 children with infectious enteritis diagnosed in Affiliated Hospital of Hebei University from September 2019 to May 2020, which were divided into bacterial enteritis group (n=76) and viral enteritis group (n=31). Another 50 children who underwent physical examination in outpatient department of our hospital were included in the healthy group. PCT, PA and NP levels of children in the three groups were compared, and the correlation between the above indicators and bacterial infectious enteritis was analyzed, as well as the diagnostic efficacy of each indicator and combined test for bacterial enteritis was explored. Results The PCT level of the bacterial enteritis group and viral enteritis group was higher than that of healthy group (P<0.05), and the PCT level of the bacterial enteritis group was higher than that of viral enteritis group (P<0.05).The PA level of the bacterial enteritis group and viral enteritis group was lower than that of healthy group (P<0.05), and the PA level of bacterial enteritis group was lower than that of viral enteritis group (P<0.05). The NP of bacterial enteritis group and healthy enteritis group was higher than that of viral enteritis group (P<0.05), The NP of bacterial enteritis group was higher than that in healthy enteritis group (P<0.05). The PCT, PA and NP levels were significantly correlated with bacterial infectious enteritis in children (P<0.05). The AUC for the combined detection of 3 indexes was 0.921, significantly higher than the PCT, PA and NP (P<0.05).The sensitivity and specificity of he combined detection of 3 indexes were higher than the PCT, PA and NP. Taking the maximum Youden index as the principle, the optimal diagnostic cutoff values of PCT, PA and NP were 1.21 ng/ml, 168.07 μg/ml and 72.98% respectively, and the combined detection was 0.563. Conclusions The PCT, PA and NP are closely related to bacterial infectious enteritis in children,and the combined detection of the three indexes can further improve the diagnostic efficiency.

Key words: Bacterial enteritis, Children, Procalcitonin, Prealbumin, Neutrophil percentage

Feng Shi, Wang Yan, Zhao Haige. Combination of procalcitonin,prealbumin and percentage of neutrophils for the diagnosis of bacterial infectious enteritis in children[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(2): 109-112.

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