Abstract: Objective The purpose is to provide references for malaria prevention and control strategy during the COVID-19 epidemic through analyzing the pathogenesis, diagnosis and treatment of the city's first imported COVID-19 case with ovale malaria. Methods The method is to carry out epidemiologic investigation on the suspected case of new crown-combined malaria who entered Shenzhen for quarantine on December 19, 2021 through the active case investigation of the Longgang District Health Station. The samples of the case were collected for testing and sent to the superior department for review. Descriptive epidemiological method was used for analysis. Investigation Results The case involves an overseas worker (male, 47 years old) who returned to China from Kenya on December 19, 2020 and was transferred to a "health station" for centralized isolation via the closed-loop management system after he landed on the airport. He was first detected positive for novel coronavirus at a nucleic acid test on December 25 and was confirmed to be positive for novel coronavirus after re-checked by the Shenzhen Center for Disease Control and Prevention. Meanwhile, the patient was tested negative in malaria antigen rapid diagnostic test (RDT) and positive for plasmodium in microscopic examination, and after fluorescence PCR test, he was confirmed to be infected with ovale malaria. Conclusion sBased on the results of the epidemiologic investigation, clinical symptoms and lab tests, the case was confirmed to be an asymptomatic COVID-19 patient with ovale malaria.

Key words: Coronavirus disease 2019, P.ovale malaria, Imported, Epidemiologic investigation