Matching analysis of propensity scores for metformin and tuberculosis infection risk in T2DM patient

doi:10.19871/j.cnki.xfcrbzz.2021.03.008

Abstract

Abstract: Objective To investigate the correlation between metformin and the risk of pulmonary tuberculosis (TB) infection in patients with type 2 diabetes (T2DM) and provide reference for the treatment of T2DM patients. Methods 179 patients with T2DM who were treated in the Department of Infectious Diseases of Enshi Minority Hospital from January 2019 to December 2019 were selected, of which 58 patients were diagnosed with TB and 121 patients did not suffer from TB. Collect the patient's use of metformin, clinical data and laboratory examination data. The two groups of patients were matched by propensity score, and then the correlation between metformin use rate and the occurrence of TB in T2MD patients after matching was analyzed by Logistic regression. Results After the propensity score matching, the use rate of metformin in the TB group was significantly lower than that in the non-TB group, and the TB exposure history and Cr were significantly higher than those in the non-TB group（χ²=9.375、4.529,t=2.112,P=0.002、0.033、0.036）. Metformin use (OR=0.368, 95% CI= 0.167-0.811) is an independent protective factor that affects the occurrence of TB, and the history of TB exposure (OR=3.007, 95% CI=1.026-8.815) is a risk factor that affects the occurrence of TB （P=0.013、0.045）. Conclusion Long-term use of metformin in T2DM patients can reduce the risk of TB. Consider the combination of metformin treatment for T2DM patients with high TB risk, thereby reducing the risk of TB.

Key words: Type Ⅱ diabetes, Tuberculosis, Metformin, Propensity score matching

Tan Yuncai, Yuan Yuan, Yang Shuangxi, Yang Xue. Matching analysis of propensity scores for metformin and tuberculosis infection risk in T2DM patient[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(3): 202-205.

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