Current situation of imipenem drug use and correlation analysis between drug resistance and common gram-negative bacteria

doi:10.19871/j.cnki.xfcrbzz.2021.03.013

Abstract

Abstract: Objective To understand the current situation of imipenem drug use and correlation analysis between drug resistance and common gram-negative pathogenic bacteria,to provide reference for clinical control of pathogen resistance. Methods Statistics from Sichuan Linshui county People's Hospital during the period of 2017–2018 imipenem drug use intensity per hundred beds and day, correlation between imipenem drug use intensity and drug resistance of common gram-negative pathogenic bacteria(Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, Haemophilus influenzae, Acinetobacter baugh) were analyzed. Results DDDs and AUD of imipenem increased significantly in 2018 while compared with 2017, and the difference was significant (P<0.05). In 2017, 327 gram-negative pathogenic bacteria were cultured and isolated. Seven hundred and sixty-five gram-negative pathogenic bacteria were cultured and isolated in 2018. One thousand and ninety-two gram-negative pathogenic bacteria were cultured and isolated in 2017–2018. Pseudomonas aeruginosa infection was mainly distributed in respiratory tract, eye-nose-mouth. Klebsiella pneumoniae, enterobacter cloacae, haemophilus influenzae and acinetobacter baugh were mainly distributed in respiratory tract.Escherichia coli were mainly distributed in eye-nose-mouth, urinary tract, blood and respiratory tract.The drug resistance rate of gram-negative pathogenic bacteria to imipenem was 6.32%, among which pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, enterobacter cloacae and haemophilus influenzae had lower drug resistance rate to imipenem, while Acinetobacter baumannii had higher drug resistance rate to imipenem. The drug resistance rate of pseudomonas aeruginosa to imipenem in 2018 was significantly higher than that in 2017, and the drug resistance rate of acinetobacter bauxis to imipenem was significantly lower than that in 2017, P<0.05. DDDs and AUD were positively correlated with pseudomonas aeruginosa, klebsiella pneumoniae and haemophilus influenzae (P<0.05), while escherichia coli was not significantly correlated (P>0.05). Conclusion It has an obvious relationship between imipenem dosage and imipenem resistance of gram-negative pathogenic bacteria. Clinicians should pay attention to the rational use of imipenem to avoid the emergence of drug-resistant bacteria.

Key words: Gram-negative bacteria, Imipenem, Drug resistance, Bacterial culture, Drug sensitive test

Chen Gang, Yang Yong, Luo Anjing, Zhang Gang, Feng Jiao. Current situation of imipenem drug use and correlation analysis between drug resistance and common gram-negative bacteria[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(3): 225-229.

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