Abstract: Objective To analyze the clinical epidemiological characteristics of 44 patients with brucellosis in Guangxi, and provide evidence for clinical diagnosis, treatment and prevention. Methods The epidemiology, clinical manifestations, auxiliary examination, treatment and prognosis of 44 cases of brucellosis patients diagnosed by affiliated infectious disease hospital of Nanning, Guangxi Medical University, from 2013 to 2020 were retrospectively analyzed. Results 95.45% of brucellosis patients had contact history with sheep or related products within six months. Fever was the first symptom in 75.00% of patients. Common clinical symptoms and signs included fever (40, 90.91%), chills (14, 31.82%), fatigue (16, 34.36%), sweating (29, 0.45%), digestive symptoms (10, 22.73%), nervous system symptoms (8, 18.18%), muscle soreness (23, 52.27%), joint pain (12, 27.27%), and hepatomegaly or splenomegaly (15, 15.91%). Serum ferritin were elevated in 36 cases of the patients(36, 81.82%). The C-reactive protein level was lightly increased in 30 cases of the patients (30, 68.18%). Conclusion The clinical manifestations and general laboratory indicators of brucellosis lack specificity. Epidemiological history has characteristic significance. Antibacterial treatment was good.

Key words: Brucella, Brucellosis, Epidemiology, Clinical feature