Abstract: China is now working with the world to achieve the goal of eliminating viral hepatitis by 2030. Chronic hepatitis B infection is a high pandemic in China. It is vital to eliminate hepatitis B virus infection from the source via blocking mother-to-child transmission (MTCT). The history of blocking hepatitis B MTCT has gone through nearly 30 years. Taking the effects of Department of Obstetrics and Gynecology, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine in preventing hepatitis B MTCT as an example, more than 30 000 chronic HBV infected pregnant women and paired infants have been included in whole-process management and prevention in the past 20 years. Among them, more than 4000 HBV infected pregnant women have been treated with antiviral therapy. From 2010 to 2015, 4820 pregnant women with hepatitis B finished MTCT follow-op while 3607 maternal-infant pairs were in the follow-up between 2016 and 2019 with an overall MTCT rate of 99.7%. Based on evidence-based medical, the management process of HBV infected pregnant women, the standardized blocking of MTCT and long-term follow-up system of infants were first established and improved. The MTCT rate has decreased from 8%-10% in 2010 to 0.3% in 2020 by achieving the process of fertility counseling, preconception screening and evaluation, antiviral therapy, infant immunoprophylax and other measures. The results have been included in domestic and international guidelines for hepatitis B prophylaxis and treatment as vital evidence-based medical evidence and have been awarded the Outstanding Contribution Award of Antiretroviral Pregnancy Registry (APR). The clinical research results have been promoted and applied in nearly 100 hospitals nationwide and more than 5000 doctors have been trained, which established a typical model for preventing hepatitis B MTCT in China. Furthermore, great social and economic benefits were obtained. Further promotion of the overall process nationwide will realize the ultimate goal of eliminating hepatitis B.

Key words: Hepatitis B, Child-bearing age, Mother-to-child transmission, Effects