Analysis of cellular immune function in patients with HBV/TP superinfection with different HBeAg status

doi:10.19871/j.cnki.xfcrbzz.2021.04.007

Abstract

Abstract: Objective To compare the cellular immune function of patients with hepatitis B virus/Treponema pallidum (HBV/TP) superinfection with different hepatitis B virus e antigen (HBeAg) status, and to further understand the changes of cellular immune function in patients with HBV/TP coinfection. Methods The clinical data of 79 patients with HBV/TP superinfection admitted to our hospital from January 2019 to January 2020 were retrospectively analyzed. All patients were divided into 2 groups according to the different HBeAg status before treatment, 41 HBeAg-positive patients were included in the HBeAg-positive group, and 38 HBeAg-negative patients were included in the HBeAg-negative group. The levels of HBV-DNA, T cell-related cytokines and T lymphocyte subsets in the peripheral blood of the two groups were compared. Results The level of HBV-DNA in the HBeAg-positive group was substantially higher than that in the HBeAg-negative group (P<0.05). The levels of CD3⁺T, CD4⁺T, CD4⁺T/CD8⁺T and natural killer (NK) cells in the HBeAg-positive group were higher than those in the HBeAg-negative group (P<0.05), and the CD8⁺T cell level was lower than that in the HBeAg-negative group (P<0.05). The levels of interferon-γ (IFN-γ), tumor necrosis factor (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17 (IL-17), transforming growth factor-β (TGF-β) in the HBeAg-positive group were substantially higher than those of the HBeAg-negative group (P<0.05). The levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) in the HBeAg-positive group were not significantly different from those in the HBeAg-negative group (P>0.05). Conclusion HBeAg level affects the immune function of patients with HBV/TP coinfection, which may induce the body to start cellular immunity, improve the level of T lymphocyte subsets and promote the secretion of related cytokines.

Key words: Hepatitis B virus e antigen, Hepatitis B virus, Treponema pallidum, Overlapping infection, Cellular immune function

Chen Siyu, Bai Lan, Zhang Jin. Analysis of cellular immune function in patients with HBV/TP superinfection with different HBeAg status[J]. Electronic Journal of Emerging Infectious Diseases, 2021, 6(4): 298-301.

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