Comparison of clinical features and prognosis of severe fever with thrombocytopenia syndrome transmitted from tick-to-person versus person-to-person

doi:10.19871/j.cnki.xfcrbzz.2022.01.006

Abstract

Abstract: Objective By analyzing the clinical features and prognostic indicators of novel phlebovirus infection in different ways induced severe fever with thrombocytopenia syndrome(SFTS), it provides a reference for the prevention and control of the disease and early prognosis. Method Retrospective analysis of the confirmed cases of SFTS from January 2015 to June 2020 in Yijishan Hospital, Wannan Medical College, according to the different transmission routes, they were divided into tick-to-persontransmission infection group (37 cases) and person-to-person transmission infection group (12 cases). The epidemiological characteristics, clinical manifestations, blood biochemical examination and prognosis were analyzed retrospectively. Result The incidence of SFTS mainly occurred in April to June, and the infection route of the person-to-person transmission infection group was contact with the blood/body fluids of the confirmed patients. The tick-to-person transmission infection group was infected by tick bites during outdoor activities.The median time from onset to treatment was 2.5 days in person-to-person transmission infection group and 5.0 days in tick-to-person transmission infection group,the difference between the two groups was statistically significant(P<0.05).The proportion of consciousness disorder in tick-to-person transmission infection group was 43.24% (16/37) higher than that in person-to-person transmission infection group.The number of critical patients in person-to-person transmission group was 16.67%(2/12), which was significantly lower than 91.89% (34/37) in tick-to-person transmission infection group. The number of deaths in ticks-to-person transmission infection group was 29.73% (11/37), but none in person-to-person transmission infection group. Conclusion The tick-to-person transmission infection group is more serious and the risk of poor prognosis is higher, so we should scientifically formulate prevention and control strategies and treatment plans for ticks infection patients.

Key words: Severe fever with thrombocytopenia syndrome, Tick- to-human transmission, Person-to-person transmission, New bunyavirus, Prognosis

Zhang Aiping, Liang Manman, Wang Zijian, Wang Wenjie, Yang Jianghua. Comparison of clinical features and prognosis of severe fever with thrombocytopenia syndrome transmitted from tick-to-person versus person-to-person[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(1): 26-29.

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