Abstract: Objective To explore the spectrum of malignant tumor in AIDS patients in our hospital, and to provide scientific data for epidemiological study and treatment of AIDS in Guangxi. Method the clinical data of 12711 AIDS patients admitted to Nanning Fourth People's Hospital from January 2014 to December 2019 were collected and analyzed. The types and distribution, age distribution and incidence rate of six cases of AIDS in hospital were analyzed. Result among the 12 711 AIDS patients, 755 cases developed malignant tumors, accounting for 5.94% of the total number, including 236 cases (1.86%) AIDS related tumors (ADCs) and 519 cases (4.08%) non-HIV defined tumors (NADCs), with 64 tumor types. The top five NADCs are malignant tumors of digestive tract, respiratory tract, female reproductive tract, urinary system and skin system. The incidence rate of malignant tumor in male patients with AIDS was significantly higher than that in female patients (χ²=11.891, P<0.01). The proportion of lymphoma and liver cancer in male AIDS patients was significantly higher than that in females (χ²= 13.594, 11.160, P<0.01), and the incidence of colorectal cancer in female patients was significantly higher than that in male patients (χ²=7.951, P<0.01). The incidence rate of malignant tumor in AIDS patients was six years, and was similar to that of lymphoma, Posey's sarcoma, respiratory tract malignant tumor and digestive tract malignant tumor. Conclusion The incidence rate of malignant tumor is higher in AIDS patients, the disease spectrum is different. Non-HIV defined cancer is the most common. The most common malignant tumor is digestive system. Men are more likely to have lymphoma and liver cancer and women are more likely to have colorectal cancer. There was a little change in the tumor spectrum over the6 year period.

Key words: Acquired immunodeficiency syndrome, Malignant tumors, Disease spectrum, Incidence rate