Analysis of risk factors of decompensated hepatitis B liver cirrhosis with bacterial infection

doi:10.19871/j.cnki.xfcrbzz.2022.01.010

Abstract

Abstract: Objective To explore the risk factors of bacterial infection associated with decompensated hepatitis B liver cirrhosis, and provide a reference for the formulation of prevention and treatment measures for bacterial infection associated with decompensated hepatitis B liver cirrhosis. Method A retrospective analysis of 316 patients with hepatitis B and liver cirrhosis who were admitted to Naval Hospital, Eastern theater of PLA from March 2019 to December 2020 in the decompensated period. Collect relevant indicators that may cause decompensation of hepatitis B liver cirrhosis accompanied by bacterial infection and cultivate pathogenic bacteria by professionals in accordance with the National Clinical Laboratory Practice Code (3rd Edition). According to the culture result, the patients were divided into positive group and negative group. The above indicators were compared between the two groups. Multivariate Logistic regression analysis was used to determine the comprehensive influence of each indicator on decompensated hepatitis B liver cirrhosis with bacterial infection. Result Among the 316 patients with hepatitis B liver cirrhosis in the decompensated stage of this investigation, a total of 73 cases (23.10%) were infected, 243 were negative (76.90%) . The result of multivariate logistic regression analysis showed that age>60 years old, child Pugh C, invasive operation, ascites, gastrointestinal bleeding, serum albumin level decreased as risk factors of bacterial infection in patients with decompensated hepatitis B cirrhosis (P<0.05). Conclusion The incidence of decompensated hepatitis B liver cirrhosis accompanied by bacterial infection is relatively high, which is mainly affected by the patient's age, Child-Pugh classification, invasive operation and other factors, and clinically targeted interventions can be developed to reduce the incidence of bacterial infections among these patients based on the these factors.

Key words: Hepatitis B, Liver cirrhosis, Decompensation period, Bacterial infection, Risk factor analysis

Chen Shangjun, Zhang Ji, Xie Husheng, Liang Xuesong. Analysis of risk factors of decompensated hepatitis B liver cirrhosis with bacterial infection[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(1): 43-46.

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