Research progress in hepatocellular carcinoma associated with hepatitis B virus and hepatitis C virus

doi:10.19871/j.cnki.xfcrbzz.2022.01.019

Abstract

Abstract: Hepatitis B virus (HBV) and hepatitis C virus (HCV) related primary hepatocellular carcinoma (HCC) is caused by complex mechanisms, which led to the host's immune dysfunction with chronic inflammation and to produce inflammatory factors that regulate multiple cancer signaling pathways. DNA fragment of HBV can insert into host genome to cause occurrence of HCC. Genome of HCV cannot be integrated into host genome, but it can induce the occurrence and progression of HCC by viral proteins and regulation of specific oncogenic pathways to induce reactive oxygen species(ROS) that damage host DNA and lead to gene mutation. Currently, in addition to the classic antiviral therapy, therapy of traditional Chinese medicine HBX targeted therapy, platelet therapy and engineered T cell therapy also show great prospects and advantages for the treatment of virus-associated HCC. In the review, we will summarize the research progress on the mechanism and treatment of HBV/HCV-associated HCC, and confer clues for future research directions.

Key words: Hepatitis B virus, Hepatitis C virus, Hepatocellular carcinoma, Mechanism, Treatment

Li Xiaoyue, Li Shujie, Yi Yongxiang. Research progress in hepatocellular carcinoma associated with hepatitis B virus and hepatitis C virus[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(1): 92-99.

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