Preliminary study of the value of Gd-EOB-DTPA enhanced MRI in evaluation of reserved liver function patients with hepatitis B

doi:10.19871/j.cnki.xfcrbzz.2022.02.013

Abstract

Abstract: Objective To investigate the value of Gd-EOB-DTPA enhanced MRI in evaluation of reserved liver function patients with hepatitis B to establish a better method of liver reserve function to guide clinical diagnosis and treatment. Method The clinical and imaging data of 78 patients with hepatitis B who underwent Gd-EOB-DTPA enhanced MRI examination admitted to You'an Hospital from January 2018 to January 2020 were retrospectively analyzed. The enhancement ratios of SNR and CNR of whole liver and liver parenchyma were measured on the images from liver acquisition of hepatobiliary phase. Patients were divided into groups according to Child-Pugh grading standard and end-stage liver disease model (MELD) scoring standard respectively: Grade A (50 cases)/Grade B (28 cases), MELD≤10 (57 cases)/MELD >10 (21 cases), signal to noise ratio (SNR) enhancement rate and contrast to noise ratio (CNR) enhancement rate were compared between groups, and the correlation between enhancement rate and liver function score was analyzed. Result There were no significant differences in SNR and CNR enhancement rates in each lobe of liver parenchyma and whole liver (P>0.05). The SNR and CNR enhancement ratios of Class A were higher than those of Class B (both P<0.05). The SNR and CNR enhancement ratios of MELD≤10 were higher than those of MELD>10 (both P<0.05). There was a negative correlation between enhancement rate and MELD score (r=-0.29, -0.31, P=0.02, 0.01). Conclusion The Gd-EOB-DTPA enhanced MRI has good evaluation value for liver function reserve of patients with hepatitis B. Measurement of the degree of parenchymal enhancement of any lobe or the whole liver on the images of Gd-EOB-DTPA -enhancement MRI in the hepatobiliary phase might reflect the reserved liver function to a certain extent.

Key words: Hepatic reserve function, Gd-Eob-DTPA, Magnetic resonance imaging, Hepatitis B

Ren Meiji, LiLi, Zhao Jing, Li Hongjun. Preliminary study of the value of Gd-EOB-DTPA enhanced MRI in evaluation of reserved liver function patients with hepatitis B[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(2): 63-66.

References

[1] MACHAIRAS N, TSILIMIGRAS DI, PAWLIK TM.State-of-the-art surgery for hepatocellular carcinoma[J]. Langenbecks Arch Surg, 2021, 406(7): 2151-2162.
[2] BIRGIN, E, KASLOW SR, HETJENS S, et al.Minimally Invasive versus Open Liver Resection for Stage I/II Hepatocellular Carcinoma[J]. Cancers, 2021, 13(19): 4800.
[3] YUAN Y, YANG F, WANG Y, et al.Factors associated with liver cancer prognosis after hepatectomy: A retrospective cohort study[J]. Medicine (Baltimore), 2021, 100(42): e27378.
[4] 林伟鸿, 李凯. 肝切除术前肝脏储备功能评估方式的新进展[J]. 中华外科杂志, 2021, 59(5): 392-396.
[5] DEMIRTAS CO, D'ALESSIO A, RIMASSA L, et al. ALBI grade: Evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma[J]. JHEP Rep, 2021, 3(5): 100347.
[6] Singal AK, Kamath PS.Model for end-stage liver disease[J]. J Clin Exp Hepatol, 2013, 3(1): 50-60.
[7] VERLOH N, HAIMERL M, ZEMAN F, et al.Assessing liver function by liver enhancement during the hepatobiliary phase with GD-EOB-DTPA-enhanced MRI at 3 Tesla[J]. Eur Radiol, 2014, 24(5): 1013-1019.
[8] 中华医学会放射学分会腹部学组. 肝胆特异性MRI对比剂钆塞酸二钠临床应用专家共识[J]. 中华放射学杂志, 2016, 50(9): 641-646.
[9] 刘志敏. 钆塞酸二钠动态增强MRI在肝脏结节定性诊断中的价值分析[J]. 临床医学工程, 2021, 28(4): 431-432.
[10] 张雪, 汤善宏, 张勇. MELD评分在终末期肝病中的临床应用进展[J]. 西南军医, 2021, 23(3): 234-237.
[11] HSU WF, CHANG KC, CHEN TH, et al.Comparison of 10 noninvasive models for predicting overall survival in patients with intermediate-stage hepatocellular carcinoma[J]. Medicine (Baltimore), 2021, 100(33): e27000.
[12] YOON JH, LEE JM, KIM E, et al.Quantitative liver function analysis: volumetric T1 mapping with fast multisection B1 inhomogeneity correction in hepatocyte-specific contrast-enhanced liver MR imaging[J]. Radiology, 2017, 282(2): 408-417.
[13] RATZIU V, CHARLOTTE F, HEURTIER A, et al.Sampling variability of liver biopsy in nonalcoholic fatty liver disease[J]. Gastroenterology, 2005, 128(7): 1898-1906.
[14] 周安, 吕志彬, 杜艳妮, 等. 钆塞酸二钠增强磁共振相对强化率与肝功能的相关性研究[J/CD]. 新发传染病电子杂志, 2021, 6(2): 88-91.
[15] CHANG CC, HUANG HC, LIU KL, et al.Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function validation with ICG tests and parenchymal cell volume[J]. Clin Imaging, 2016, 40(4): 797-800.
[16] SHIMAMOTO D, NISHIE A, ASAYAMA Y, et al.MR prediction of liver function and pathology using GD-EOB-DTPA: effect of liver volume consideration[J]. Biomed Res Int, 2015, 2015: 141853.
[17] KATSUBE T, OKADA M, KUMANO S, et al.Estimation of liver function using T1 mapping on Gd-EOB-DITPA-enhanced magnetic resonance imaging[J]. Invest Radiol, 2011, 46(4): 277-283.
[18] YOON JH, CHOI JI, JEONG YY, et al.Pre-treatment estimation of future remnant liver function using gadoxetic acid MRI in patients with HCC[J]. J Hepatol, 2016, 65(6): 1155-1162.
[19] 周忠洋, 向颜韩, 廖锦元. 钆塞酸二钠增强磁共振T1-mapping评估肝纤维化评分的研究[J/CD]. 新发传染病电子杂志, 2020, 5(3): 178-182.
[20] SHI Z, CAI W, FENG X, et al.Radiomics Analysis of Gd-EOB-DTPA Enhanced Hepatic MRI for Assessment of Functional Liver Reserve[J]. Academic radiology, 2022, 29(2): 213-218.