Progress on Talaromycosis in non-HIV-infected patients

doi:10.19871/j.cnki.xfcrbzz.2022.02.018

Abstract

Abstract: Talaromyces marneffei is an opportunistic pathogen, which mainly occurs in human immunodeficiency virus (HIV)-infected patients. Whereas, non-HIV Talaromycosis patients increased in recent years which was related to the compromised immune conditions of hosts. The most common underlying diseases in children were various primary immunodeficiency diseases. The most common underlying diseases in adults were anti-interferon-gamma autoantibody (AIGA) syndrome, autoimmune diseases, glucocorticoid and/or immunosuppressive therapy, malignancy, diabetes and so on. Most non-HIV Talaromycosis patients occurred disseminated infection, and might coinfected with other opportunity pathogens and had secondary hemophagocytic lymphohistiocytosis. The clinical manifestations and prognosis of non-HIV Talaromycosis patients were different from that of HIV-infected patients. Herein, we reviewed the epidemiology, immunodeficiency, clinical manifestations, diagnosis, treatment and prognosis of non-HIV Talaromycosis.

Key words: Talaromycosis, Immunodeficiency, Clinical manifestations, Treatment

Huang Liping, Lu Aili, Peng Jie. Progress on Talaromycosis in non-HIV-infected patients[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(2): 89-94.

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