Abstract: Since 1981, when the World Health Organization (WHO) recommended the use and provision of free multidrug therapy（MDT）, the global prevalence of leprosy has declined sharply, and Shenzhen achieved the goal of basic eliminate leprosy as early as 1996 and has maintained a low prevalence status since then. Currently, the control target has changed from reducing the prevalence index to eliminating leprosy hazards, and China is working together with the world to achieve the goal of "zero leprosy" by 2030. Shenzhen follows a series of international and domestic leprosy prevention and treatment strategies and guidelines, adheres to the working mechanism of "no change in policy, no reduction in funding, no dispersion of teams, no stopping of work", focuses on the prevention and treatment principles of "whole population, public welfare, convenience and accessibility", adheres to the policy of "prevention first, prevention and treatment combined", takes the consolidation of the basic elimination of leprosy as the central goal, focuses on the elimination of leprosy hazards, organizes and implements the integrated medical and prevention integration model of prevention and control with government-led policy formulation, technical support from professional institutions, and multi-sectoral cooperation and response. A series of leprosy prevention and control strategies and measures with Shenzhen characteristics have been carried out proactively and comprehensively, including "establishing and improving the three-level prevention and control network and epidemic monitoring system, implementing and optimizing the symptom surveillance case detection model, the whole-population whole-process service model, the deformity prevention and rehabilitation service model, and strengthening capacity building and quality control". From 2010 to 2021, Shenzhen has maintained zero new cases of childhood leprosy and zero recurrent cases of leprosy, and the ratio of grade 2 deformity disability cases among new leprosy cases is 14.9%, which is at a low level in China. The key strategic measures and progress implemented by Shenzhen in the process of eliminating leprosy hazards and moving towards zero leprosy provide the basis for the next step in the development and adjustment of comprehensive leprosy prevention and control strategies and for accelerating the achievement of "zero leprosy".

Key words: Leprosy, Prevention and control strategies and measures, Zero leprosy, Zero recurrent case