Potential efficacy of combined use of albuvirtide and dolutegravir in newly diagnosed AIDS patients

doi:10.19871/j.cnki.xfcrbzz.2022.03.004

Abstract

Abstract: Objective To analyze the short-term efficacy and immune function of albuvirtide and dolutegravir in newly treated patients with AIDS,and to assess its efficacy. Method 186 patients with AIDS were collected from March 2020 to February 2021. Patients received ABT combined with DTG for 4 weeks,then observed the the curative effect and immune level,and statistically analyzed. Result After 4 weeks of ABT + DTG combined treatment, the plasma HIV RNA of patients was significantly decreased (t=32.87, P<0.001), and some patients were lower than the detection limit (<40 copies/ml). At the same time, the immune function of patients was significantly improved after 4 weeks of ABT + DTG combination therapy (P=0.001).The results showed that regardless of the baseline HIV RNA level, the serum CD4+T lymphocyte level (P<0.001) and CD4+T/CD8+T ratio were significantly increased (P=0.005). Immune function reconstruction is more obvious, especially in patients with high viral load. Conclusion For newly diagnosed AIDS patients, the ABT+DTG antiviral therapy can rapidly reduce HIV RNA levels and improve the immune function in the short term, regardless of the HIV viral load in the body. It can improve the immune function of patients, and make patients benefit significantly. It provide a valuable treatment plan for newly diagnosed AIDS patients.

Key words: Human immunodeficiency virus, Albuvirtide, Dolutegravir, Efficacy

Zhu Yingchun, Cai Lin. Potential efficacy of combined use of albuvirtide and dolutegravir in newly diagnosed AIDS patients[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(3): 18-21.

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