Abstract: Objective To quantitatively measure intracranial T1 value, T2 value and PD value of AIDS patients with MAGiC technology, and to explore the application value of MAGiC sequence in the diagnosis of HIV-related neurocognitive disorders. Method From May 2021 to September 2021, 38 hiv-infected patients were examined by magnetic resonance MAGiC technology in Shenzhen Third People's Hospital were retrospectively analyzed. According to the presence of HIV-associated neurocognitive disorder (HAND), the patients were divided into two groups (23 cases in the non-HAND group and 15 cases in the HAND group), and 18 cases without HIV infection were selected as the normal control group. T1-mapping (MS), T2-mapping (MS) and proton density PD(PU) values of both centrum semiovale, anterior horn of lateral ventricle, posterior horn of lateral ventricle, both basal ganglia, genu of corpus callosum, brainstem and ce-rebellum were quantitatively measured by MAGiC technique.The independent samples Kruskal-Wallis test was used for comparison between two groups, and the ROC curve was drawn. Result ①The T1 value of each measuring point in the HAND group was higher than that in the non-HAND group and the normal control group, and the difference was statistically significant (P<0.05); ②There were no significant differences in T1,T2 and PD values between the non-HAND group and the normal control group (P>0.05); ③T1 is the most effective for distinguishing HAND from non-hand. The area under the curve of T1 value in the right basal ganglia was 0.897, the sensitivity was 1, the specificity was 0.725, P<0.001, and the optimal diagnostic threshold was 998.33ms. Conclusion The T1 value of each intracranial part of HAND patients is significantly higher than that of non-HAND patients and non-HIV-infected patients. Quantitative measurement of T1 value can reflect whether HIV-infected patients.

Key words: Human immunodeficiency virus, Cognitive dysfunction, Magnetic resonance, Quantitative imaging techniques