Abstract: Objective To analyze the epidemiological characteristics of 719 cases of HIV/AIDS with malignant tumors in a single center. Method Data were extracted from medical records of 719 patients diagnosed as HIV/AIDS with malignant tumors in Public Health Clinical Center of Chengdu from March 2017 to March 2021. And epidemiological characteristics,including tumor-AIDS relationship, and type of malignancy of HIV/AIDS with malignant tumors were analyzed. Result Among the 719 patients, AIDS-related tumors (ADCs) accounted for 29.49%(212/719), and non-AIDS-related tumors (NADCs) accounted for 70.51%(507/719); 72.46%(521/719) cases were males, Top 3 tumors: non-Hodgkin Lymphoma, lung cancer, liver cancer; 27.54%(198/719) cases were females, Top 3 tumors: cervical cancer, non-Hodgkin Lymphoma, lung cancer, the distribution of HIV/AIDS with malignant tumors between genders was statistically different（P<0.001）; Among the patients of age groups, non-Hodgkin Lymphoma(41/165, 70/404) was the highest in young and middle-aged patients with malignant tumors, and lung cancer (32/150) was the highest in elderly patients; Among the patients of ethnic groups, non-Hodgkin Lymphoma (116/719,3/719) was the highest in Han Chinese and Tibetan, and Kaposi's sarcoma (6/719) was the highest in Li Chinese, the distribution of genders, and ethnicity among types of malignant tumors was statistically significant different（P<0.001）. Conclusion Among patients diagnosed as HIV/AIDS with malignant tumors, non-Hodgkin Lymphoma(NHL) was more common in male, and the young and middle-aged; Lung cancer was more common in the old, while cervical cancer was more in female. Besides, Han Chinese and Tibetan were prone to be NHL, but Yi Chinese was Kaposi sarcoma. Attention should be paid to such people.

Key words: Human immunodeficiency virus, Acquired immune deficiency syndrome, AIDS related tumors, Malignancy, Epidemiology, Ethnicity