Abstract: In this paper, the current diagnostic technologies of clinical TB are reviewed according to the way of phenotype technology, immunological technology genetic technology, mass spectrometry technology and et al. Phenotype technologies include microscope test technology, isolation and culture technology, phage lysis assay technology, other phenotypic laboratory diagnostic technology and et al. Immunology protein diagnostic technologies include traditional immunology technology, Enzyme linked immunospot assay and Interferon gamma release assay, colloidal gold immunochromatographic test card technology and et al. Genetics diagnosis technologies include semi-nested PCR amplification technology, fluorescence probe PCR melting curve technology, loop mediated isothermal amplification technology, Linear probe Geno Type MTBDRplus technology, whole genome sequencing. The destination is to explore the advantages and disadvantages of different detection technology in the diagnosis and drug susceptibility test(DST) of TB at present, and to look forward to the continuous improvement of TB test technologies in the future, so as to provide reference for the selection of suitable test technologies for laboratories of different grades and functions.

Key words: Mycobacterium tuberculosis, Phenotype, Genotype, Immunology, Mass spectrometry technology