Correlation between Gd-EOB-DTPA enhanced MRI and histologic grade of hepatocellular carcinoma in hepatitis B

doi:10.19871/j.cnki.xfcrbzz.2022.04.011

Abstract

Abstract: Objective A retrospective analysis was performed to analyze the the correlation between quantitative indicators by gadoxetic acid disodium enhanced MRI and the differentiation degree of hepatocellular carcinoma. Method A total of 38 patients who pathologically confirmed for HCC in hepatitis B which were divided into high(10 patients), medium(21 patients) and low(7 patients) groups at our institution between June 2020 and June 2021 were retrospectively analyzed. Gadoxetic acid enhanced MRI was performed in all patients before surgery. The SNR of liver parenchyma, LLC, CER and SIR of HCC were calculated. The comparisons of these quantitative data among different grades were performed. Result Among 38 patients, 7 were poorly differentiated, 21 were moderately differentiated and 10 were well differentiated. The SNR of hepatic parenchymal in plain scan and arterial phase (AP) were lower than those in portal venous phase (PVP) and hepatobiliary phase (HP) (P<0.05). The LLC value of well differentiated HCC was higher than moderately differentiated HCC in plain scan and HP; the CER value of well differentiated HCC was lower than moderately and poorly differentiated HCC in AP; The value of SIR of well differentiated HCC was higher than moderately and poorly differentiated HCC in plain scan, and well differentiated was higher than moderately differentiated in HP; all the differences were statistically significant (P<0.05). Conclusion The quantitative index LLC, CER and SI ratios of Gd-EOB-DTPA-enhanced MRI were correlated with the histological differentiation of hepatocellular carcinoma, which could provided value for the evaluation of hepatocellular carcinoma with different degrees.

Key words: Hepatitis B, Hepatocellular carcinoma, Histological grade, Gadolinium ethoxybenzyl diethylene-triamine-pentaacetic-acid, Magnetic resonance imaging

Du Yanni, Lyu Zhibin, Xing Yuxue, Guan Chunshuang, Zhang Zixin, Xie Ruming, Chen Budong. Correlation between Gd-EOB-DTPA enhanced MRI and histologic grade of hepatocellular carcinoma in hepatitis B[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(4): 47-52.

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