Prevalence of neurosyphilis among syphilis serofast patients: a Meta-analysis

doi:10.19871/j.cnki.xfcrbzz.2022.04.015

Abstract

Abstract: Objective To estimate the prevalence of neurosyphilis among syphilis serofast patients and analyze its associated factors using a meta-analysis approach. Method Key words with syphilis serofast and neurosyphilis were searched in the Chinese National Knowledge Infrastructure (CNKI), Wan Fang Database and PubMed. Literatures with clear definitions of syphilis serofast and neurosyphilis, and reporting the numbers of both serofast patients and neurosyphilis patients were collected. Statistical analysis was performed in the R software. Result A total of 769 literatures were retrieved, and 23 literatures were finally included. The included literatures involved 2103 syphilis serofast patients, among whom 420 were neurosyphilis patients. The prevalence of neurosyphilis among serofast patients was 18% (95% CI: 13% to 25%) in the random-effects model. The prevalence rates varied with serofast patients' age (χ²=104.82, P<0.001) and the follow-up time to define serofast (χ²=139.44, P<0.001). The positive rates of neurosyphilis testing also varied with detection methods of cerebrospinal fluid (χ²=137.86, P<0.001). Conclusion Syphilis serofast patients have high prevalence of neurosyphilis. It is necessary to conduct more researches on the relationships between syphilis serofast and neurosyphilis, and thus provide more scientific data for the formulation of syphilis prevention and control policies.

Key words: Syphilis, Serofast, Neurosyphilis, Meta-analysis

Wu Xiaobing, Mao Yajun, Liu Xin, Guan Yang, Zheng Jinfen. Prevalence of neurosyphilis among syphilis serofast patients: a Meta-analysis[J]. Electronic Journal of Emerging Infectious Diseases, 2022, 7(4): 65-69.

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