Abstract: Objective This paper describes the clinical features of three cases with hemophagocytic syndrome in AIDS patients and compares them with literature data. This is to deepen the understanding of the disease. Method A retrospective analysis was conducted to collect the basic information, clinical manifestations, laboratory tests and outcome characteristics of 3 patients diagnosed with AIDS and hemophagocytic syndrome in Public and Health Clinical Center of Chengdu from March 2020 to December 2021, and to review the literature. Result The 3 cases included 2 males and 1 female. The average age was 38. All patients were diagnosed with AIDS. Fever, splenic and multiple lymph node enlargement, methemoglobinemia, and blood system damage were the common clinical characteristics of 3 patients. Laboratory examination showed that sCD25 was significantly increased, NK cell activity was decreased, hemophagy of the bone marrow smear was observed, and EBV-DNA was detected in the blood. 3 cases were complicated with opportunistic infection, which failed to respond to anti-infective therapy. The disease progressed rapidly and all cases were died. Conclusion The case of AIDS complicated with HPS is rare, and infection is the common cause. Because variable clinical symptoms are easily confused with other diseases,low correct diagnosis rate of HPS is found among these patients. The control of HPS is as important as ART.But this disease progresses rapidly, resulting in high mortality. Doctors should be alert to the occurrence of HPS among these patients.

Key words: Acquired immune deficiency syndrome, Hemophagocytic syndrome, Case-reporting